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Wendell Y. Yap, M.D.

Assistant Professor, Radiology
wyap@kumc.edu

Professional Background

Have been in Radiology practice for almost 20 years. My major emphasis has been in Oncologic imaging, Nuclear Medicine, Molecular Imaging and Theranostics. I am also part of the Body imaging team wherein I interpret CT and MR body images.
Through out the years, I have been an advocate for Nuclear Medicine and Molecular imaging. At the University of Kansas Health System, we have been actively utilizing different radiophamaceuticals for imaging of various conditions utilizing gamma camera, SPECT-CT and PET-CT. Scans being performed include bone scans, hepatobiliary scans,ventilation/perfusion lung scan, thyroid uptake and scan, renal scans, gastric emptying study, GI bleed scans, Meckel's scan, Octreoscan for neuroendocrine tumors and paraganglioma, MIBG scan for pheochromocytoma and neuroblastoma as well as various PET imaging such as F18 FDG scans, Ga68 dotatate scan for neuroendocine tumors, F18 fluciclovine/ FACBC (Axumin) for prostate cancer, N13 amminia myocardial perfusion scan and coming soon is Ga 68 PSMA scan for prostate cancer to name a few.
Currently, I am also active in theranostics with various radioactive treatments utilizing unsealed sources, for example I131 hyperthyroid and thyroid cancer therapy, Lu177 dotatate (Lutathera) therapy for gastroenteropancreatic neuroendocrine tumor and coming soon Lu177 PSMA therapy for prostate cancer.

Education and Training
  • BS, Major in Biology, Univ. of Santo Tomas, Philippines
  • MD, Doctor of Medicine and Surgery, Univ. of Santo Tomas, Philippines
  • Internship, Multiple specialties, Santo Tomas University Hospital, Manila, Philippines
  • Internship, Multiple specialties, Santo Tomas University Hospital, Manila, Philippines
  • Other, Diagnostic Radiology, Santo Tomas University Hospital, Manila, Philippines
  • Residency, Diagnostic Radiology, Santo Tomas University Hospital, Manila, Philippines
  • Clinical Fellowship, MRI Fellow, St. Joseph Medical Center, Burbank, CA
  • Internship, Multiple specialties, Deaconess Medical Center, St. Louis, MO
  • Residency, Nuclear Medicine, Loyola University Medical Center, Maywood, IL
Licensure, Accreditations & Certifications
  • Diplomate, American Board of Nuclear Medicine
  • Diplomate, American Board of Radiology
  • Licensed Physician and Surgeon, Illinois Department of Financial and Professional Regulation
  • Medical Doctor, Kansas State Board of Healing Arts
  • Medical Physician and Surgeon, Missouri Division of Professional Registration
  • Physician and Surgeon, Medical Board of California
Professional Affiliations
  • Society of Nuclear Medicine and Molecular Imaging PET Center of Excellence, Member, 2015 - Present
  • University of Kansas Health System, Radiation Safety Committee, Member, 2007 - Present
  • Society of Nuclear Medicine and Molecular Imaging Missouri Valley Chapter, Member, 2001 - Present
  • Greater Kansas City Radiological Society, Member, 1997 - Present
  • Society of Nuclear Medicine and Molecular Imaging, Member, 1997 - Present
  • Radiologic Society of North America, Member, 1995 - Present

Research

Overview

My major emphasis has been in Oncologic imaging, Nuclear Medicine, Molecular Imaging and Theranostics.
I am actively participating as co-investigator in various clinical studies wherein radiopharmaceuticals are utilized for diagnostic imaging , for staging and restaging of cancer patients as well as therapy for example in I131 CLR, Ac123 Lintuzumab and Ra223 therapies. With theranostics as an emerging field, I am looking at the efficacy of Lu177 dotatate (Lutathera) therapy for gastroenteropancreatic neuroendocrime tumors and soon Lu177 PSMA for prostate cancer therapy.

Current Research and Grants
  • A Multicenter Pivotal Phase 3 Study of Iomab B Prior to Allogeneic Hematopoietic Cell Transplantation versus Conventional Care in Older Subjects with Active, Relapsed or Refractory Acute Myeloid Leukemia , Clinical Research Project. University of Kansas Cancer Center
  • A Phase 1 Study of Lintuzumab-Ac225 in Patients with Refractory Multiple Myeloma, Human Subjects Committee. The University of Kansas Cancer Center
  • Alzheimer's Prevention Program, Human Subject Committee. The University of Kansas Hospital
  • Alzheimer’s Prevention through Exercise, Human Subject Committee. The University of Kansas Medical Center
  • An Open-Label, Multicenter, Phase 2 Study of CLR 131 in Patients with Relapsed or Refractory (R/R) Select B-Cell Malignancies (CLOVER-1) Cobalt-57 Evaluation of Dosimetric Imaging in a Multicenter Pivotal Phase 3 Study of Iomab B Prior to Allogenic Hematopoietic Cell Transplantation versus Conventional Care in Older Subjects with Active, Relapsed or Refractory Acute Myeloid Leukemia, Human Subject Committee. University of Kansas Cancer Center
  • Cobalt-57 Evaluation of Dosimetric Imaging in a Multicenter Pivotal Phase 3 Study of Iomab B Prior to Allogenic Hematopoietic Cell Transplantation versus Conventional Care in Older Subjects with Active, Relapsed or Refractory Acute Myeloid Leukemia, Human Subjects Committee. The University of Kansas Cancer Center
Publications
  • Spencer, Jayden, Yap, Wendell, Dusing, Reginald, Hill, Jacqueline, Walter, Carissa. 2019. Intravascular Large B-Cell Lymphoma Presenting with Diffusely Increased Pulmonary FDG Up-take without Corresponding CT Abnormality.. Radiology Case Report, 14 (2), 260 - 264
  • Wendell, Yap. 2020. Imaging-Based Biodistribution and Dosimetry of Anti-CD45 Iodine Apamistamab (iomab-B) for Targeted Conditioning in Older Patients with Active, Relapsed, or Refractory Acute Myelogenous Leuikemia Peior to Hematopoietic Stem Cell Transplant (HCT): Preliminary Results from the Prospective, Randomized Phsase 3 SIERRA Trial.. SNM-MI
  • Old, J, Dusing, Reginald, Yap, Wendell, Dirks, J. 2005. Imaging for Suspected Appendicitis. American Family Physician, 71 (1), 71 - 78
  • Ackerman, Leo, Yap, Wendell, Shirazi, Parvez, VanDrumen, M. 1998. Ga-67 Imaging of Penile Abscess.. Clinical Nuclear Medicine, 23 (2), 112 - 113
  • Yap, Wendell. 1997. Vasotec Renal Scintigraphy in the Evaluation of Renovascular Hypertension. Applied Radiology, 26 (6), 5 - 8