Graduate Student - Ding Lab
B.S. in Pharmaceutical Science, Sun Yat-sen University, Guangzhou, China
M.S. in Pharmacology, Sun Yat-sen University, Guangzhou, China
I come from Guangzhou, China, and got my Bachelor and Master degree from Sun Yat-sen University. During my graduate study, my research project was focusing on studying activities of novel compounds against Alzheimer's disease and cerebral ischemia, and the underlying mechanisms. I joined Dr. Wen-Xing Ding's lab in 2015 as a research assistant and became a graduate student in 2016.
Macroautophagy is an evolutionarily conserved process for degradation of macromolecules and damaged organelles in cytoplasm of eukaryotic cells. In this process, the double-membrane autophagosomes engulf individual organelles, protein aggregates, or portions of cytoplasm, and fuss with lysosomes to form autolysosome and resulting in the degradation of their contents by lysosomal enzymes. In this process, lysosomal biogenesis might play an important role in regulation of autophagy activity. Transcription factor EB (TFEB) is a master regulator and transcription factor for the gene expression of lysosomal biogenesis and autophagy-related genes. My current research is to study the role of TFEB in alcohol/Acetaminophen-induced liver injury.