Graduate Student - Jaeschke Lab
My name is Jephte Akakpo and I completed a MSc degree in biological engineering. Since August 2016, I am a graduate student in toxicology in the Department of Pharmacology, Toxicology and Therapeutics at the University of Kansas Medical Center. My goal is to become a translational toxicologist in the field of drug hepatotoxicity and acute liver failure.
My research interest focuses on understanding the molecular and cellular mechanisms of acetaminophen (APAP) hepatotoxicity, which is the main cause of acute liver failure in western countries. My thesis work, which is supported by an F31 grant from NIH, involves both basic mechanistic studies of the role of mitochondrial biogenesis in APAP-induced liver injury and translational efforts to repurpose existing drugs for clinical use in APAP overdose. Currently I am working on 4-methylpyrazole, an FDA approved drug for methanol and ethylene glycol poisoning as a complement to the standard of care, N-acetyl cysteine.