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COBRE Overview

The department of Pharmacology, Toxicology, and Therapeutics was originally awarded a Center for Biomedical Research Excellence (COBRE) grant on June 1, 2006 and subsequently renewed on September 2, 2011, by the National Center for Research Resources (NCRR), a division of the National Institute of Health (NIH), grant numbers P20 RR021940 (Years 1-5) and P20 GM103549 (Years 6-10). The title of the grant is "The Role of Nuclear Receptors in Liver Health and Disease".  The purpose of this COBRE grant is to mentor junior faculty and establish core laboratories with the long-term goal of establishing a liver center to study liver functions in health and disease.

Administrative Core

Hartmut Jaeschke, Ph.D. Bruno Hagenbuch, Ph.D.
Hartmut Jaeschke, Ph.D.,
Professor and Chair
Bruno Hagenbuch, Ph.D.,
Professor and Vice Chair


The Administrative Core is responsible for overall oversight, organization and the management of the scientific aspects of the COBRE grant.  In addition to the scientific oversight, the core provides a number of support services to Program-associated investigators, including fiscal/budgetary management, preparation of progress reports, scheduling of research meetings for project-associated investigators, coordinating travel arrangements and meetings of the external science advisory board (EAB), and organizing a regular scientific seminar program and administering a small graduate research training class.

External Science Advisory Board (EAB)

D. Montgomery Bissell, M.D. John Chiang, Ph.D. Robert Hanzlik, Ph.D. Steven Kliewer, Ph.D. Joseph Locker, M.D., Ph.D.
D. Montgomery Bissell, M.D.
University of California,
San Francisco
John Chiang, Ph.D.
Northeastern Ohio University
Robert Hanzlik, Ph.D.
University of Kansas,
Steven Kliewer, Ph.D.
University of Texas,
Southwestern Medical Center
Joseph Locker, M.D., Ph.D.
University of Pittsburgh

Last modified: Sep 28, 2018