Michael L. Lydic, MD
Clinical Associate Professor
Obstetrics and Gynecology
MD, Hahnemann (Drexel) University
Internship & Residency, Hahnemann University Hospital
Fellowship, University of Cincinnati College of Medicine
My research interests include Polycystic Ovarian Syndrome (PCOS) and associated insulin-resistance, diminished ovarian reserve, recurrent pregnancy loss, effects of supplements/over-the-counter products on reproductive function, and assisted reproduction. I have previously studied the effect of chromium picolinate, a safe dietary hexavalent form of chromium, on insulin sensitivity in obese PCOS patients with insulin resistance. I utilized a high dose regimen of chromium picolinate, based upon studies in diabetic patients, and assessed glucose disposal rate via euglycemic hyperinsulinemic clamp both before and after administering 3 months of chromium picolinate. I have also comparatively assessed Homeostatic Model Assessment (HOMA) in comparison to glucose/insulin ratio in PCOS. I have also previously investigated the use of high dose folate in recurrent pregnancy loss patients with normal homocysteine levels and Methyltetrahydrofolate Reductase Mutation.
Lydic ML, McDowell M. Application of a Modified HOMA to Estimate Glucose Disposal Rate and Comparison with Fasting Glucose/Insulin Ration in the Detection of Insulin Resistant Polycystic Ovarian Syndrome. Poster Presentation (P-463), ASRM 2004 Annual Meeting, Philadelphia, PA.
Van Den Heuvel K, Lydic ML. Administration of high dose folate may benefit women with recurrent first trimester pregnancy loss and normal homocysteine with MTHFR mutation. Poster Presentation (P-909). ASRM 2006 Annual Meeting, New Orleans, LA.
Lydic ML, C-reactive protein, but not triglyceride/HDL ratio, Correlates with body mass index and homocysteine markers of insulin sensitivity in women with polycystic ovarian syndrome (POSC). Poster Presentation (P-887), ASRM 2006 Annual Meeting, New Orleans, LA.
Lydic ML, Liu JH, Thomas MA, Cedars MI, Rebar RW. Success of donor oocyte in vitro fertilization-embryo transfer in recipients with and without premature ovarian failure. Fertil Steril 65:98-l02, l996.
Quinn P, Lydic ML, HO M, Bastuba M, Hendee F, Brody SA. Confirmation of the beneficial effects of brief coincubation of gametes in human in vitro fertilization. Fertil Steril 69(3): 399-402,1998.
Lydic ML, McNurlan M, Bembo S, Mitchell L, Komaroff E, Gelato M. Chromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome. Fertil Steril 86(1):243-6, 2006.
Lydic ML, Juturu V. Dietary approaches and alternative therapies for the management of PCOS. Curr Nutr Food Sci 2008.