Michael J. Soares, PhD
Director, Institute for Reproduction and Perinatal Research
Director, Center for Perinatal Research
University Distinguished Professor
Pathology and Laboratory Medicine
PhD, University of Hawaii, 1981
Postdoctoral, University of California, Santa Cruz, 1981-1983
Postdoctoral, Baylor College of Medicine, Houston, Texas, 1983-1984
Our laboratory investigates specialized survival strategies used by the embryo as it grows within the uterus. Central to the embryo's survival is the formation of an organ derived from the embryo called the placenta. This organ gains access to the maternal blood supply and facilitates the delivery of nutrients to the fetus. We study how early stem cells develop into the placenta. We have learned that the placenta is built in response to cues present in the maternal environment; and diseases of pregnancy, such as preeclampsia and intrauterine growth restriction, result when the embryo is not successful in its adaptations to the maternal environment. Inadequate in utero adaptive responses have potentially long-lasting impacts on adult health and disease.
For more information on our research, please visit the Soares Lab web site.
Kubota, K., Kent, L.N., Rumi, M.A.K., Roby, K.F., and Soares, M.J. (2015) Dynamic regulation of AP-1 transcriptional complexes directs trophoblast differentiation. Molecular and Cellular Biology 35: 3163-3177.
Renaud, S.J., Chakraborty, D., Mason, C.W., Rumi, M.A.K., Vivian, J.L., and Soares, M.J. (2015) OVO-like 1 regulates progenitor cell fate in human trophoblast development. Proceedings of the National Academy of Sciences U.S.A. 112: E6175-E6184.
Dhakal, P., Rumi, M.A.K., Kubota, K., Chakraborty, D., Chien, J., Roby, K.F., and Soares, M.J. (2015) Neonatal progesterone programs adult uterine responses to progesterone and susceptibility to reproductive dysfunction. Endocrinology 156: 3791-3803.
Kubota, K., Cui, W., Dhakal, P., Wolfe, M.W., Rumi, M.A.K., Vivian, J.L., Roby, K.F., and Soares, M.J. (2016) Rethinking progesterone regulation of female reproductive cyclicity. Proceedings of the National Academy of Sciences U.S.A. 113: 4212-4217.
Chakraborty, D., Cui, W., Rosario, G.X., Scott, R.L., Dhakal, P., Renaud, S.J., Tachibana, M., Rumi, M.A.K., Mason, C.W., Krieg, A.J., and Soares, M.J. (2016) HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Proceedings of the National Academy of Sciences U.S.A. 113: E7212-E7221.
Renaud, S.J., Scott, R.L., Chakraborty, D., Rumi, M.A.K., and Soares, M.J. (2017) Natural killer cell deficiency alters placental development in rats. Biology of Reproduction 96: 145-158.
Soares, M.J., Varberg, K.M., and Iqbal, K. (2018) Hemochorial placentation: development, function, and adaptations. Biology of Reproduction 99: 196-211.