Alan Yu, M.B., B.Chir.
Professor and Director
Kidney Institute Director
School of Medicine, Internal Medicine
B.A., University of Cambridge, England
M.B., B.Chir., University of Cambridge, England
Internal Medicine Residency, Brigham & Women's Hospital, Harvard Medical School
Nephrology Fellowship, Brigham & Women's Hospital, Harvard Medical School
Research Interests: Dr. Yu directs a laboratory-based research program that investigates renal tubule physiology and diseases. A current focus is on understanding paracellular epithelial transport and its regulation. Paracellular transport occurs through tight junctions and is mediated by a family of channels called claudins. The investigation of claudins promises to reveal novel fundamental insights into the pathogenesis of many diseases, including acute kidney injury, salt-sensitive hypertension and kidney stone disease. Dr. Yu also performs clinical research in polycystic kidney disease. He is particularly interested in translating bench research findings about cell signaling pathways into drugs and therapeutics, especially repurposed drugs, and testing them in early phase human trials.
Clinical Interests: Dr. Yu is a general nephrologist who sees the full spectrum of kidney diseases. He has a special interest in fluid, electrolyte and acid-base disorders, including hyponatremia, hypernatremia, hypokalemia, hyperkalemia, hypomagnesemia, renal tubular acidosis, and inherited tubulopathies, particularly Barrter's and Gitelman's syndrome.