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Mihaela E. Sardiu, Ph.D.

Associate Professor, Department of Biostatistics & Data Science

B.S. Physics, University of Bucharest, Romania
M.S. Physics, University of Bucharest, Romania
Ph.D., Physics, Florida Atlantic University, Boca Raton, FL.
Post-Doc, Stowers Institute for Medical Research, Kansas City, MO
Certificate in Data Science from Johns Hopkins through Coursera


Research Focus

Dr. Sardiu is a theoretical physicist with extensive experience in molecular modeling, bioinformatics and translational research. Dr. Sardiu’s research interest is in the field of quantitative omics data, with a focus on the development of computational methods for processing and extracting biological information from large and complex datasets. One of the aims of dr. Sardiu is to develop new methods for integrative analyses of data across different data types with a goal to identify potentially cancer-related molecular alterations and determine new disease biomarkers. Another priority of Dr. Sardiu is to provide a holistic view of merged data and interpretation tools that harmonize biological information across heterogeneous platforms. Lastly, a new focus is on exploring perturbed networks structures and trying to address the dynamics of networks in general using statistical physics principles.

Selected Publications

Identification of stem cells from large cell populations with topological scoring. Sardiu ME, Box AC, Haug JS, Washburn MP.Mol Omics. 2020 Sep 14. doi:

The chromatin bound proteome of the human malaria parasite. Batugedara G, Lu XM, Saraf A, Sardiu ME, Cort A, Abel S, Prudhomme J, Washburn MP, Florens L, Bunnik EM, Le Roch KG.Microb Genom. 2020 Feb;6(2):e000327. doi: 10.1099/mgen.0.000327. Epub 2020 Feb 4.PMID: 32017676 Free PMC article.

A Systems Chemoproteomic Analysis of Acyl-CoA/Protein Interaction Networks. Levy MJ, Montgomery DC, Sardiu ME, Montano JL, Bergholtz SE, Nance KD, Thorpe AL, Fox SD, Lin Q, Andresson T, Florens L, Washburn MP, Meier JL.Cell Chem Biol. 2020 Mar 19;27(3):322-333.e5. doi: 10.1016/j.chembiol.2019.11.011. Epub 2019 Dec 10.PMID: 31836350

Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo. Nil Z, Hervás R, Gerbich T, Leal P, Yu Z, Saraf A, Sardiu M, Lange JJ, Yi K, Unruh J, Slaughter B, Si K.Cell. 2019 Oct 17;179(3):801. doi: 10.1016/j.cell.2019.09.033.

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome. Dayebgadoh G, Sardiu ME, Florens L, Washburn MP.J Proteome Res. 2019 Sep 6;18(9):3479-3491. doi: 10.1021/acs.jproteome.9b00373. Epub 2019 Aug 9.PMID: 31353912 Free PMC article.

Topological scoring of protein interaction networks. Sardiu ME, Gilmore JM, Groppe BD, Dutta A, Florens L, Washburn MP.Nat Commun. 2019 Mar 8;10(1):1118. doi: 10.1038/s41467-019-09123-y.

The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry. Vilhais-Neto GC, Fournier M, Plassat JL, Sardiu ME, Saraf A, Garnier JM, Maruhashi M, Florens L, Washburn MP, Pourquié O.Nat Commun. 2017 Sep 28;8(1):728. doi: 10.1038/s41467-017-00593-6.PMID: 28959017 Free PMC article.

Identification of Topological Network Modules in Perturbed Protein Interaction Networks. Sardiu ME, Gilmore JM, Groppe B, Florens L, Washburn MP.Sci Rep. 2017 Mar 8;7:43845. doi: 10.1038/srep43845.PMID: 28272416 Free PMC article.

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.
Gilmore JM, Sardiu ME, Groppe BD, Thornton JL, Liu X, Dayebgadoh G, Banks CA, Slaughter BD, Unruh JR, Workman JL, Florens L, Washburn MP.PLoS One. 2016 Jun 1;11(6):e0155492. doi: 10.1371/journal.pone.0155492. eCollection 2016.PMID: 27248496 Free PMC article.

Conserved abundance and topological features in chromatin-remodeling protein interaction networks.
Sardiu ME, Gilmore JM, Groppe BD, Herman D, Ramisetty SR, Cai Y, Jin J, Conaway RC, Conaway JW, Florens L, Washburn MP.EMBO Rep. 2015 Jan;16(1):116-26. doi: 10.15252/embr.201439403. Epub 2014 Nov 26.PMID: 25427557 Free PMC article.

Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes. Sardiu ME, Lee KK, Swanson SK, Gilmore JM, Torok M, Grant PA, Florens L, Workman JL, Washburn MP.Mol Syst Biol. 2011 Jul 5;7:503. doi: 10.1038/msb.2011.40.PMID: 21734642 Free PMC article.

Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics.
Sardiu ME, Cai Y, Jin J, Swanson SK, Conaway RC, Conaway JW, Florens L, Washburn MP.Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1454-9. doi: 10.1073/pnas.0706983105. Epub 2008 Jan 24.PMID: 18218781 Free PMC article.

Cysteine-cysteine contact preference leads to target-focusing in protein folding. Sardiu ME, Cheung MS, Yu YK.Biophys J. 2007 Aug 1;93(3):938-51. doi: 10.1529/biophysj.106.097824.PMID: 17617551 Free PMC article.

Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae.
Zybailov B, Mosley AL, Sardiu ME, Coleman MK, Florens L, Washburn MP.J Proteome Res. 2006 Sep;5(9):2339-47. doi: 10.1021/pr060161n.PMID: 16944946

Score statistics of global sequence alignment from the energy distribution of a modified directed polymer and directed percolation problem. Sardiu ME, Alves G, Yu YK.Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Dec;72(6 Pt 1):061917. doi: 10.1103/PhysRevE.72.061917. Epub 2005 Dec 23.PMID: 16485984

Last modified: Feb 18, 2021

Sardiu

Contact

Mihaela E. Sardiu, Ph.D.
Associate Professor, Department of Biostatistics & Data Science

P: (913) 588-4703
F: (913) 588-0252
msardiu@kumc.edu

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