Director, Mass Spectrometry Laboratory
University Distinguished Professor
Regulation of gene expression in animal cells, regulaton of cell proliferation and differentiation, molecular genetics of kidney disease.
Thermodynamic and biophysical probes of the molecular mechanism of allosteric enzymes.
Regulation of gene transcription. Gap junctional coupling in neuronal survival and death.
Genome Maintenance: Elucidating how DNA damage is generated, processed and repaired using structural and biochemical approaches.
Role of hormones in breast cancer, crosstalk beween the immune system and steroid receptor action
Membrane proteins in apoptotic regulation and cancer targeting, Bcl-2 proteins, bacterial toxins, antimicrobial peptides, biophysical techniques.
Research Assistant Professor
Professor and Vice Chair
Human beta-globin gene regulation using transgenic mice and cell lines generated with beta-globin locus yeast artifical chromosomes.
Protein degradation in the cell. Biochemical and cell biological analyses of assembly and localization of proteasomes and their autophagic degradation.
The role of post-translation modification in cell cycle progression and development; glycobiology; signal transduction.
Professor and Chair
Applications of protein evolution to personalized medicine and protein engineering; transcriptional regulation of bacterial metabolism.
Transport across biological membranes, ion channels, membrane protein biochemisty, X-ray crystallography, single particle cryo-EM