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Seth Holwerda, PhD

Assistant Professor
Department of Anesthesiolgy

PH.D., 2015, University of Missouri, department of Medical Pharmacology and Physiology
Post-doctoral Research Fellow, 2015-2020, University of Iowa, Department of Health and Human Physiology

Publications: My Bibliography - NCBI

Professional Affiliations:

  • American Heart Association
  • American Autonomic Society

Research Interest:

My lab is currently focused on understanding the neural mechanisms that explain the high prevalence of hypertension among patients with chronic pain and the potential for neuromodulation to function as an effective intervention. We are also examining the question of why hypertension and diabetes often develop together by using high fidelity measurements of sympathetic neural activity (microneurography) and vascular function in adults across the continuum of impaired glucose control. The primary aim is to develop effective interventions to prevent or attenuate hypertension and microvascular damage in these patient populations.

Kansas Neural Cardiovascular Control Laboratory

Selected Publications:

1. Holwerda SW, Kardon RH, Hashimoto R, Full JM, Nellis JK, DuBose LE, Fiedorowicz JG, Pierce GL. Association between aortic stiffness and end-organ retinal microvascular flow pulsatility in healthy humans. J Appl Physiol. (In press) (PMID: 32437246)

2. Holwerda SW, Holland MT, Green AL, Pearson ACS, Pierce GL. Dissociation between reduced pain and arterial blood pressure following epidural spinal cord stimulation in patients with chronic pain: A retrospective study. Clin Auton Res. (In press) (PMID: 32323062)

3. Holwerda SW, Luehrs RE, DuBose LE, Majee R, Pierce GL. Sex and age differences in the association between sympathetic outflow and central elastic artery wall thickness in humans. Am J Physiol Heart Circ Physiol. 317(13):H552-H560, 2019. (PMID: 31274352)

4. Young BE, Holwerda SW, Vranish JR, Keller DM, Fadel PJ. Sympathetic transduction in type 2 diabetes: Impact of statin therapy. Hypertension 74:201-207, 2019. (PMID: 31188673)

5. Holwerda SW, Luehrs RE, Collins MT, Wooldridge NA, Stroud AK, Fadel PJ, Abboud FM, Pierce GL. Elevated muscle sympathetic nerve activity contributes to central artery stiffness in young and middle-age/older adults. Hypertension 73(5):1025-1035, 2019. (PMID: 30905199)

6. Holwerda SW, Luehrs RE, Gremaud AL, Woolridge NA, Stroud AK, Fiedorowicz JG, Abboud FM, Pierce GL. Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety. J Neurophysiol. 120(1):11-22, 2018. (PMID: 29537916)

7. Holwerda SW, Holland MT, Reddy CG, Pierce GL. Femoral vascular conductance and peroneal muscle sympathetic nerve activity responses to acute epidural spinal cord stimulation in humans. Exp Physiol 103(6):905-915, 2018. (PMID: 29603444)

8. Vranish JR, Holwerda SW, Young BE, Creduer DP, Patik JC, Barbosa TC, Keller DM, Fadel PJ. Exaggerated vasoconstriction to spontaneous bursts of muscle sympathetic nerve activity in healthy young black men. Hypertension 71(1):192-198, 2018. (PMID: 29203629)

9. Holwerda SW, Vianna LC, Restaino RM, Chaudhary K, Young CN, Fadel PJ. Arterial baroreflex control of sympathetic nerve activity and heart rate in patients with type 2 diabetes. Am J Physiol Heart Circ Physiol. 311(5):H1170-H1179, 2016. (PMID: 27591221)

10. Holwerda SW, Restaino RM, Fisher JP, Fadel PJ. Augmented pressor and sympathetic responses to skeletal muscle metaboreflex activation in type 2 diabetes patients. Am J Physiol Heart Circ Physiol. 15;310(2):H300-9, 2016. (PMID: 26566729)

Last modified: Nov 09, 2020

Seth Holwerda


Seth Holwerda, PhD
Assistant Professor

Mailstop 1034
3901 Rainbow Blvd
Kansas City, KS 66160

My Bibliography - NCBI