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The EDGE lab is actively engaged in multiple significant research projects and aims to create discoveries to help the health of our community. Scientists are working to better understand the immune response to radical cystectomy surgery in bladder cancer patients. The EDGE lab is also exploring the influence of energy balance on prostate cancer progression.

Publications

• Hamilton-Reeves JM, Stanley A, Bechtel MD, Yankee TM, Chalise P, Hand LK, Lee EK, Smelser W, Mirza M, Wyre H, Hull H, Carlson SE, Holzbeierlein JM. Perioperative Immunonutrition Modulates Inflammatory Response after Radical Cystectomy: Results of a Pilot Randomized Controlled Clinical Trial. J Urol. 2018 Mar 6. pii: S0022-5347(18)42469-X. doi: 10.1016/j.juro.2018.03.001. [Epub ahead of print] PubMed PMID: 29518432. 
• Coss-Bu JA, Hamilton-Reeves JM, Patel JJ, Hurt RT, and Morris CR. Protein Requirements of the Critically Ill Pediatric Patient. Nutrition in Clinical Practice. 2017 Apr;32(1_suppl):128S-141S. doi: 10.1177/0884533617693592. Epub 2017 Mar 1. PMID: 28388381
• Patel JJ, McClain CJ, Sarav M, Hamilton-Reeves JM, and Hurt RT. Protein Requirements for Critically-Ill Patients with Renal and Liver Failure. Nutrition in Clinical Practice. 2017 Apr;32(1_suppl):101S-111S. doi: 10.1177/0884533616687501. Epub 2017 Feb 16. PMID: 28208022
• Morris CR, Hamilton-Reeves JM, Martindale R, Hoffer JL, Sarav M, and Ochoa Gautier J. Acquired Amino Acid Deficiencies: A Focus on Arginine and Glutamine. Nutrition in Clinical Practice. 2017 Apr;32(1_suppl):30S-47S. doi: 10.1177/0884533617691250. Epub 2017 Feb 1. PMID: 28388380
• Hurt RT, McClave SA, Martindale RG, Ochoa J, Coss-Bu JA, Dickerson RN, Heyland DK, Hoffer, J, Moore FA, Morris CR, Paddon-Jones D, Patel JJ, Phillips S, Rugeles S, Sarav M, Weijs PJM, Wernerman  J, Hamilton-Reeves JM, McClain CJ, Taylor B. Summary Points and Consensus Recommendations from the International Protein Summit. Nutrition in Clinical Practice. 2017 Apr;32(1_suppl):142S-151S. doi: 10.1177/0884533617693610. PMID: 28388374
• Tobert CM, Hamilton-Reeves JM, Norian LA, Hung C, Brooks NA, Holzbeierlein JM, Downs TM, Robertson DP, Grossman R, Nepple KG*. The emerging impact of malnutrition on surgical patients: literature review and potential implications on cystectomy for bladder cancer. J Urol. 2017 Mar 9. pii: S0022-5347(17)39247-9. doi: 10.1016/j.juro.2017.01.087. PMID: 28286066*authors contributed equally
• Luo T, Smith S, Zhao B, Sullivan D, Hamilton-Reeves JM, Guthrie G, Ricketts ML, Shiverick KT, Shay NF. Gene Expression Patterns are Altered in Athymic Mice and Metabolic Syndrome Factors are Reduced in C57BL/6J Mice Fed High-fat Diets Supplemented with Soy Isoflavones. Journal of Agricultural and Food Chemistry. 2016 Oct 12;64(40):7492-7501. 
• Taylor JM, Hamilton-Reeves JM, Sullivan DK, Gibson CA, Creed C, Carlson SE, Wesson DE, Grantham JJ. Experiences and perspectives of polycystic kidney disease patients following a diet of reduced osmoles, protein, and acid precursors supplemented with water: A qualitative study. PLoS One. 2016 Aug 18;11(8):e0161043. doi: 10.1371/journal.pone.0161043. PMID: 27537328
• Luo T, Miranda-Garcia O, Adamson A, Hamilton-Reeves JM, Sullivan D, Kinchen JM, Shay NF. Consumption of walnuts in combination with other whole foods produces physiologic, metabolic, and gene expression changes in obese C57BL/6J high-fat fed mice. (Accepted-in press). Journal of Nutrition. 2016 Sep;146(9):1641-50. doi: 10.3945/jn.116.234419. PMID: 27489005
• Snyder SM, Zhao B, Luo T, Kaiser C, Cavender G, Hamilton-Reeves J, Sullivan DK, Shay NF. Consumption of Quercetin and Quercetin-Containing Apple and Cherry Extracts Affects Blood Glucose Concentration, Hepatic Metabolism, and Gene Expression Patterns in Obese C57BL/6J High Fat-Fed Mice. Journal of Nutrition. 2016 Apr 6. pii: jn228817. PMID: 27052533
• Hamilton-Reeves JM, Bechtel MD, Hand LK, Schleper A, Yankee TM, Chalise P, Lee EK, Mirza M, Wyre H, Griffin J, Holzbeierlein JM. Effects of Immunonutrition for Cystectomy on Immune Response and Infection Rates: A Pilot Randomized Controlled Clinical Trial. European Urology. 2016 Mar;69(3):389-92. doi: 10.1016/j.eururo.2015.11.019. Epub 2015 Nov 30. PMID: 26654125 *Impact Factor of 14, top ranked journal in Urology
• Schleper A, Sullivan DK, Thrasher J, Holzbeierlein JM, Klemp J, Befort C, Hamilton-Reeves JM. Weight management to reduce prostate cancer risk: a survey of men's needs and interests Cancer and Clinical Oncology. 2016 May; 5(1):43-52.
• Taylor JM, Hamilton-Reeves JM, Sullivan DK, Gibson CA, Creed C, Carlson SE, Wesson DE, Grantham JJ. Diet and polycystic kidney disease: A pilot intervention study. Clinical Nutrition. 2016 Jan 11. pii: S0261- 5614(16)00005-4. doi: 10.1016/j.clnu.2016.01.003. PMID: 26811129
• Taylor JM, Oladitan L, Carlson S, Hamilton-Reeves JM. Renal formulas pretreated with medications alters the nutrient profile. Pediatric nephrology 2015; 30(10):1815-23. NIHMSID: NIHMS719524 PubMed PMID: 25930981 PMCID: PMC4572699
• B Diggett, J Holzbeierlein, J Klemp, C Glennon, D Kueker, and JM Hamilton-Reeves. Patient-centered perspectives on the access to educational opportunities specific to lifestyle modification in men at risk for primary or secondary prostate cancer. Journal of Cancer Education 2014 Jun;29(2):252-7. PMID: 24214853 doi: 10.1007/s13187-013-0583-9.
• K Robien, SJ Oppeneer, JA Kelley, JM Hamilton-Reeves. Drug-vitamin D interactions: a systematic review of the literature. Nutrition in Clinical Practice 2013 Apr;28(2):194-208. doi: 10.1177/0884533612467824. Epub 2013 Jan 10. PMID: 23307906
• JM Hamilton-Reeves, S Banerjee, SK Banerjee, J Holzbeierlein, JB Thrasher, S Kambhampati, J Keighley, and P Van Veldhuizen. Short-term soy isoflavone intervention in patients with localized prostate cancer: a randomized, double-blind, placebo-controlled trial. PLoS One 2013 Jul 12;8(7):e68331. doi: 10.1371/journal.pone.0068331. PMID: 23874588
• Hamilton-Reeves JM, Stanley A, Bechtel MD, Yankee TM, Chalise P, Hand LK, Lee EK, Smelser W, Mirza M, Wyre H, Hull H, Carlson SE, Holzbeierlein JM. Perioperative Immunonutrition Modulates Inflammatory Response after Radical Cystectomy: Results of a Pilot Randomized Controlled Clinical Trial. J Urol. 2018 Mar 6. pii: S0022-5347(18)42469-X. doi: 10.1016/j.juro.2018.03.001. [Epub ahead of print] PubMed PMID: 29518432. 
• Coss-Bu JA, Hamilton-Reeves JM, Patel JJ, Hurt RT, and Morris CR. Protein Requirements of the Critically Ill Pediatric Patient. Nutrition in Clinical Practice. 2017 Apr;32(1_suppl):128S-141S. doi: 10.1177/0884533617693592. Epub 2017 Mar 1. PMID: 28388381
• Patel JJ, McClain CJ, Sarav M, Hamilton-Reeves JM, and Hurt RT. Protein Requirements for Critically-Ill Patients with Renal and Liver Failure. Nutrition in Clinical Practice. 2017 Apr;32(1_suppl):101S-111S. doi: 10.1177/0884533616687501. Epub 2017 Feb 16. PMID: 28208022
• Morris CR, Hamilton-Reeves JM, Martindale R, Hoffer JL, Sarav M, and Ochoa Gautier J. Acquired Amino Acid Deficiencies: A Focus on Arginine and Glutamine. Nutrition in Clinical Practice. 2017 Apr;32(1_suppl):30S-47S. doi: 10.1177/0884533617691250. Epub 2017 Feb 1. PMID: 28388380
• Hurt RT, McClave SA, Martindale RG, Ochoa J, Coss-Bu JA, Dickerson RN, Heyland DK, Hoffer, J, Moore FA, Morris CR, Paddon-Jones D, Patel JJ, Phillips S, Rugeles S, Sarav M, Weijs PJM, Wernerman  J, Hamilton-Reeves JM, McClain CJ, Taylor B. Summary Points and Consensus Recommendations from the International Protein Summit. Nutrition in Clinical Practice. 2017 Apr;32(1_suppl):142S-151S. doi: 10.1177/0884533617693610. PMID: 28388374
• Tobert CM, Hamilton-Reeves JM, Norian LA, Hung C, Brooks NA, Holzbeierlein JM, Downs TM, Robertson DP, Grossman R, Nepple KG*. The emerging impact of malnutrition on surgical patients: literature review and potential implications on cystectomy for bladder cancer. J Urol. 2017 Mar 9. pii: S0022-5347(17)39247-9. doi: 10.1016/j.juro.2017.01.087. PMID: 28286066*authors contributed equally
• Luo T, Smith S, Zhao B, Sullivan D, Hamilton-Reeves JM, Guthrie G, Ricketts ML, Shiverick KT, Shay NF. Gene Expression Patterns are Altered in Athymic Mice and Metabolic Syndrome Factors are Reduced in C57BL/6J Mice Fed High-fat Diets Supplemented with Soy Isoflavones. Journal of Agricultural and Food Chemistry. 2016 Oct 12;64(40):7492-7501. 

Selected Abstracts

Food & Nutrition Conference & Expo, Academy of Nutrition and Dietetics
October 2017; Chicago, IL
Poster presentation: “Diet Quality During Weight Maintenance in Rural Breast Cancer Survivors”

American Urologic Association Annual Meeting
May 2017; Boston, MA
Poster presentation: “Malnutrition Status and An Intervention for Malnutrition in Patients Undergoing Radical Cystectomy”

American Urologic Association Annual Meeting
May 2017; Boston, MA
Moderated poster presentation: “Feasibility of a weight management program tailored for overweight men with localized prostate cancer: a pilot study”

American Society for Parenteral Nutrition, Clinical Nutrition Week
February 2017; Orlando, FL
Oral presentation: “Effects of Oral Immunonutrition on Cytokine Profiles in Bladder Cancer Patients: A Pilot Randomized Controlled Clinical Trial” *Abstract of Distinction Award Winner

American Institute of Cancer Research
November 2016; Washington DC
Poster: “Feasibility of a weight management program tailored for overweight men with localized prostate cancer: a pilot study”

South Central Section of the American Urologic Association
September 2016; Colorado Springs, CO
Podium: “Effects Of A Weight Loss Program Tailored For Overweight And Obese Men With Localized Prostate Cancer On Risk Factors For Cardiovascular Disease”

South Central Section of the American Urologic Association
September 2016; Colorado Springs, CO
Poster: “Effectiveness Of A Weight Loss Program Tailored For Overweight And Obese Men With Localized Prostate Cancer”

South Central Section of the American Urologic Association
September 2016; Colorado Springs, CO
Poster: “Effects Of A Weight Loss Program Tailored For Overweight And Obese Men With Localized Prostate Cancer On Risk Factors For Cardiometabolic Disease”

South Central Section of the American Urologic Association
September 2016; Colorado Springs, CO
Podium: “Malnutrition Status and An Intervention For Malnutrition In Patients Undergoing Radical Cystectomy”

South Central Section of the American Urologic Association
September 2016; Colorado Springs, CO
Poster: “Influence Of Oral Immunonutrition On Vitamin A Status In Cystectomy: Results From A Randomized Controlled Clinical Trial”

South Central Section of the American Urologic Association
September 2016; Colorado Springs, CO
Poster: “Effects Of Oral Immunonutrition On Cytokine Profiles In Bladder Cancer Patients: A Pilot Randomized Controlled Clinical Trial”