The Histopathology Core supports the COBRE projects by facilitating the rapid phenotype analysis of transgenic or null mice. For example, in determining gene expression pathways that are regulated in the liver of OB/SHP null mice as compared to control OB/OB and SHP null mice under different conditions. The functions of the core include determining gross histological characteristics of tissue, measuring and localizing protein and gene expression in liver or other tissues by immunocytochemistry or in situ hybridization techniques, perform serum chemistry analysis to follow liver injury and repair during studies of fibrogenesis or fatty liver, and quantitating different cell types isolated from the liver or other sources by flow cytometry.
All Histopathology Core instruments are located in 4044 Hemenway Life Sciences Innovation Center. This lab is open from 7:00 AM to 6:00 PM Monday through Friday, excluding holidays.
Training from Huina Cai is required before using instrument. Please contact Huina Cai to arranage a time for training. Once trained, you will schedule instrument time via the Pharmacology, Toxicology SharePoint site.
Wen-Xing Ding, Ph.D
Histopathology Core Technician