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Mengwei Niu

Mengwei Niu

Professional Background

I got my Ph.D. degree in Pathophysiology of Southern Medical University in 2022. During my Ph.D. training, I have investigated the relationship between acute liver diseases and gut microbiota.  Specifically, I investigated the role of gut barrier in acetaminophen induced acute liver failure. In Nov. 2022, I joined Dr. Wen-Xing Ding’s lab as a postdoc. While I am open to explore various projects in the Ding Lab focusing on autophagy-related proteins in liver diseases, I am interested in studying the potential synergistic role of alcohol consumption in acetaminophen hepatotoxicity and the underlying mechanisms. I am also characterizing the role of VMP1, an ER membrane protein, in metabolic changes in multiple different metabolic tissues in mice under the guidance of Drs Wen-Xing Ding and Hongmin Ni. Outside of the lab and science, I like doing some outdoor activities.

Education and Training
  • Ph.D. in Pathophysiology, Southern Medical University, China
  • B.S. in Nursing, Henan University of Science and Technology, China

Publications
  • Niu M, Chen P. Crosstalk between gut microbiota and sepsis. Burns Trauma. 2021 Oct 26;9:tkab036. doi: 10.1093/burnst/tkab036. PMID: 34712743; PMCID: PMC8547143.
  • Zeng L, Wang Y, Li N, Niu M, Wang Y, Chen P. Protective Effect of a Novel (2S, 3R, 4S)-Chromene-3-Carboxamide Derivative, Z20 Against Sepsis-Induced Organ Injury. Inflammation. 2020 Aug;43(4):1222-1232. doi: 10.1007/s10753-019-01174-z. PMID: 32462546.
  • Niu MW, Chen P. Gut microbiota and drug-induced liver injury: an update. Chin Med J (Engl). 2020 Feb 20;133(4):494-495. doi: 10.1097/CM9.0000000000000651. PMID: 31977551; PMCID: PMC7046259.
  • Qu Y, Yang C, Li X, Luo H, Li S, Niu M, Chen P, Yan Z, Jiang Y. CpG-Oligodeoxynucleotides Alleviate Tert-Butyl Hydroperoxide-Induced Macrophage Apoptosis by Regulating Mitochondrial Function and Suppressing ROS Production. Oxid Med Cell Longev. 2020 May 9;2020:1714352. doi: 10.1155/2020/1714352. PMID: 32454932; PMCID: PMC7232733.
  • Niu M, Luo Z, Gong S, Win S, Kaplowitz N, Jiang Y, Chen P. Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice. Am J Pathol. 2020 Jan;190(1):57-67. doi: 10.1016/j.ajpath.2019.09.009. Epub 2019 Oct 11. PMID: 31610172; PMCID: PMC6943379.
  • He Z, Wei G, Li N, Niu M, Gong S, Wu G, Wang T, Jiang Y, Chen P. CCR2 and CCR5 promote diclofenac-induced hepatotoxicity in mice. Naunyn Schmiedebergs Arch Pharmacol. 2019 Mar;392(3):287-297. doi: 10.1007/s00210-018-1576-3. Epub 2018 Nov 27. Erratum in: Naunyn Schmiedebergs Arch Pharmacol. 2020 Sep;393(9):1777-1778. PMID: 30483860.
  • Gong S, Yan Z, Liu Z, Niu M, Fang H, Li N, Huang C, Li L, Chen G, Luo H, Chen X, Zhou H, Hu J, Yang W, Huang Q, Schnabl B, Chang P, Billiar TR, Jiang Y, Chen P. Intestinal Microbiota Mediates the Susceptibility to Polymicrobial Sepsis-Induced Liver Injury by Granisetron Generation in Mice. Hepatology. 2019 Apr;69(4):1751-1767. doi: 10.1002/hep.30361. Epub 2019 Mar 5. PMID: 30506577.
  • Liu Z, Li N, Fang H, Chen X, Guo Y, Gong S, Niu M, Zhou H, Jiang Y, Chang P, Chen P. Enteric dysbiosis is associated with sepsis in patients. FASEB J. 2019 Nov;33(11):12299-12310. doi: 10.1096/fj.201900398RR. Epub 2019 Aug 28. PMID: 31465241; PMCID: PMC6902702.
  • Wang J, Gong S, Wang F, Niu M, Wei G, He Z, Gu T, Jiang Y, Liu A, Chen P. Granisetron protects polymicrobial sepsis-induced acute lung injury in mice. Biochem Biophys Res Commun. 2019 Jan 22;508(4):1004-1010. doi: 10.1016/j.bbrc.2018.12.031. Epub 2018 Dec 11. PMID: 30551881.
  • Wu G, Niu M, Tang W, Hu J, Wei G, He Z, Chen Y, Jiang Y, Chen P. L-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice. J Transl Med. 2018 Dec 7;16(1):344. doi: 10.1186/s12967-018-1718-x. Erratum in: J Transl Med. 2020 Jul 8;18(1):276. PMID: 30526624; PMCID: PMC6286552.
School of Medicine

The University of Kansas Medical Center
Pharmacology, Toxicology & Therapeutics
Mailstop 1018
3901 Rainbow Boulevard
Kansas City, KS 66160
913-588-7500