Giselle Sanchez-Guerrero

Professional Background

I was born and raised in Santiago, Chile. I got my bachelor’s degree in Biochemistry from the University de Santiago de Chile in 2016. My undergraduate thesis project was about the development of nanoparticles as gene carriers for immunotherapies against cancer. After graduation, I worked as Research Assistant in Chile on a project focusing on the research of stress markers in S. salar. I came to the US to work as a research technician in the radiation oncology department at KUMC. I joined the IGPBS program in 2019 and Dr. Jaeschke's lab in the Department of Pharmacology, Toxicology, and Therapeutics in June 2020.

Research interest

Overdose of acetaminophen, a commonly used analgesic, can cause acute liver injury and is the leading cause of acute liver failure in the US. My research focus is to elucidate molecules and pathways involved in acetaminophen-induced inflammation, and on how the activation of these signaling pathways can induce the expression of cytokines that promote immune cell infiltration. Our goal is to achieve the characterization of the immune cells (and mechanisms) involved in acetaminophen-hepatotoxicity and how these immune cells can alter the micro-environment of the necrotic area to facilitate an anti-inflammatory immune cell phenotype, enhancing liver regeneration and recovery after an acetaminophen overdose.