Recent Publications

Ray, S., Saha, A., Ghosh, A., Roy, N., Kumar, R.P., Meinhardt, G., Mukerjee, A., Gunewardena, S., Kumar, R., Knöfler, M., Paul, S. (2022) Hippo signaling cofactor, WWTR1, at the crossroads of human trophoblast progenitor self-renewal and differentiation. Proc. Natl. Acad. Sci. (USA), 2022 Sep 6;119(36):e2204069119.  doi: 10.1073/pnas.2204069119. Epub 2022 Aug 29. PMCID: PMC9457323.

Bhattacharya, B., Home, P., Ganguly, A., Ray, S., Ghosh, A., Islam, R., French, V., Marsh, C., Gunewardena, S., Okae, H., Arima, H.,  and  Paul, S. (2020) Atypical Protein Kinase C iota (PKCλ/ι) Ensures Mammalian Development by Establishing the Maternal-Fetal Exchange Interface. Proc Natl Acad Sci (USA), Jun 23;117(25):14280-14291. doi: 10.1073/pnas.1920201117. PMCID:PMC7322033.

Saha, B., Ganguly, A., Home, P., Bhattacharya, B., Ray, S., Ghosh, A., Rumi, M.A.K., Marsh, C., French, V., Gunewardena, S., and Paul, S. (2020) TEAD4 Ensures Post-implantation Development by Promoting Trophoblast Self-Renewal: An Implication in Early Human Pregnancy Loss. Proc. Natl. Acad. Sci. (USA), 2020 Jul 28;117(30):17864-17875. doi: 10.1073/pnas.2002449117. Epub 2020 Jul 15. PMCID: PMC7395512.

Milano-Foster, J., Ray, S., Home, P., Ganguly, A., Bhattacharya, B., Bajpai, S., Pal, A., Mason, C. W., Paul, S. (2019) Regulation of human trophoblast syncytialization by histone demethylase LSD1. J Biol Chem. 2019 Nov 15;294(46):17301-17313. doi: 10.1074/jbc.RA119.010518. Epub 2019 Oct 7. PMCID: PMC6873176.

Kumar. R. P., Ray, S., Home, P., Saha, B., Bhattacharya, B., Wilkins, H.M., Chavan, H., Ganguly, A., Milano-Foster, A., Krishnamurthy, P., Swerdlow, R. H., Paul, A., and Paul, S. (2018) Regulation of Energy Metabolism during Early Mammalian Development: TEAD4 Controls Mitochondrial Transcription. Development 145(19) doi: 10.1242/dev.162644.

Paul, S., Home, P., Bhattacharya, B., Ray, S. (2017) GATA factors: Master regulators of gene expression in trophoblast progenitors. Placenta S0143-4004(17)30268-0. doi: 10.1016/j.placenta.2017.05.005.

Home, P., Kumar, R. P., Ganguly, A., Saha, B., Foster, J. M., Bhattacharya, B., Ray, S., Gunewardena, S., Paul, A., Camper, S. A., Fields, P. E. and Paul, S. (2017) Genetic Redundancy of GATA Factors in Extraembryonic Trophoblast Lineage Ensures Progression of both Pre and Postimplantation Mammalian Development. Development 144(5):876-888. doi: 10.1242/dev.145318.

Selected Prior Publications

Aljitawi O S, Paul, S, Ganguly A, Lin TL, Ganguly S, Vielhauer G, Capitano ML, Cantilena A, Lipe B, Mahnken JD, Wise A, Berry A, Singh AK, Shune L, Lominska C, Abhyankar S, Allin D, Laughlin M, McGuirk JP, Broxmeyer HE. (2016) Erythropoietin modulation is associated with improved homing and engraftment after umbilical cord blood transplantation. Blood 128:3000-3010.

Paul, A., Danley, M., Saha, B., Tawfik, O., Paul S. (2015) PKCζ Promotes Breast Cancer Invasion by Regulating Expression of E-cadherin and Zonula Occludens-1 (ZO-1) via NFκB-p65. Sci Rep.;5:12520. doi: 10.1038/srep12520

Carey, T. S., Cao, Z., Choi, I., Ganguly, A., Wilson, C. A., Paul, S., Knott, J. G. (2015) BRG1 governs Nanog transcription in early mouse embryos and embryonic stem cells via antagonism of histone H3 lysine 9/14 acetylation. Mol Cell Biol. 35(24):4158-69. doi: 10.1128/MCB.00546-15. Epub 2015 Sep 28

Cao, Z., Carey, T. S., Ganguly, A., Wilson, C. A., Paul, S., Knott, J. G. (2015) Transcription factor AP-2γ induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage. Development. 142:1606-15. PMCID: PMC4419278

Mahato, B., Home, P., Rajendran, G., Paul, A., Saha, B., Ganguly, A., Ray, S., Roy, N., Swerdlow, R.H., and Paul, S. (2014) Regulation of Mitochondrial Function and Cellular Energy Metabolism by Protein Kinase C-: A Novel Mode of Balancing Pluripotency. Stem Cells 32: 2880-2892. PMCID: PMC4198455

Paul, A., Gunewardena, S., Stecklein, S., Saha, B., Parelkar, N., Dan;ey, M., Rajendran, G., Home, P., Ray, S., Jokar, I., Vielhauer, G., Jensen, R., Tawfik, O., and Paul, S. (2014) “PKCλ/ι Signaling Promotes Triple Negative Breast Cancer Growth and Metastasis" Cell Death and Dif. 21:1469-1481. PMCID: PMC4131178

Paul, S., and Knott, G., (2014) Epigenetic control of cell fate in mouse blastocyst: The role of covalent histone modifications and chromatin remodeling. Mol. Reprod. Dev. 81:172-82.

Rajendran, G., Dutta, D., Hong, J., Paul, A., Saha, B., Mahato, B., Ray, S., Home, P., Gangly, A., Weiss, M. L., and Paul, S. (2013) Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J. Biol. Chem. 288:24351-62. PMCID: PMC3750137.

Yoshinaga, K., PrabhuDas, M., Davies, C., White, K., Caron, K., Golos, T., Fazleabas, A., Paria, B., Mor, G., Paul, S., Ye, X., Dey, S. K., Spencer, T., Roberts, R. M. (2013). Interdisciplinary collaborative team for blastocyst implantation research: inception and perspectives. Am J. Reprod. Immunol. 71:1-11.

Hong J, He H, Bui P, Ryba-White B, Rumi MA, Soares MJ, Dutta D, Paul S, Kawamata M, Ochiya T, Ying QL, Rajanahalli P, Weiss ML (2012), A focused microaaray for screening rat embryonic stem cells. (2013) Stem Cell. Dev. 22(3):431-43.

 Saha, B., Home, P., Ray, S., Pal, A., Larson, M., Rajendran, G., Behr, B., and Paul, S. (2013) EED and KDM6B Coordinate First Mammalian Cell Lineage Commitment to Ensure Embryo Implantation.  Mol. Cell. Biol. 33(14):2691-705. PMCID: PMC3700131.

Home, P., Saha, B., Dutta, D., Ray, S., Pal, A., Gunewardena, S., Yoo, B., Vivian, J. L., Larson, M., Petroff, M., Gallagher, P. G., Schulz, V., White, K.L., Golos, T. G., Behr, B., and Paul, S. (2012) Altered Subcellular Localization of Transcription Factor TEAD4 Regulates First Mammalian Cell Lineage Commitment. Proc. Natl. Acad. Sci. U.S.A. 109(19):7362-7.

Dutta, D., Ray, S., Home, P., Larson, M., Wolfe M.W., and Paul, S. (2011) Self Renewal vs. Lineage Commitment of Embryonic Stem Cells: Protein Kinase C Signaling Shifts the Balance. STEM CELLS 29(4):618-28.

Dutta, D., Ray, S., Home, P., Wang, S., Sheibani, N., Tawfik, O., Cheng, N., and Paul, S. Regulation of Angiogenesis by Histone Chaperone HIRA-Mediated Incorporation of Lysine 56-Acetylated Histone H3.3 at Chromatin Domains of Endothelial Genes. J. Biol. Chem. (285:41567-77)

Home, P., Ray, S., Dutta, D., Bronshteyn, I., Larson, M., and Paul, S. (2009) GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates CDX2 gene expression. J. Biol. Chem.284: 28729-37

Ray, S., Dutta, D., Rumi, M., Canham, L., Soares, M. J., and Paul, S. (2009) Context-dependent function of regulatory elements and switch in chromatin occupancy between GATA3 and GATA2 regulate Gata2 trasncription during trophoblast differentiation. J. Biol. Chem. 284:4978-4988.

Dutta, D., Ray, S., Vivian, J. L., and Paul, S. (2008) Activation of the VEGFR1 chromatin domain: An angiogenic signal-ETS1/HIF-2alpha regulatory axis. J. Biol. Chem. 283:25404-25413.