Tikhanovich Lab
Dr. Irina Tikhanovich, Ph.D.
Assistant Professor, Department of Internal Medicine, Division of Gastroenterology/Hepatology
My research interests focus on the role of epigenetic regulators, specifically involved in histone arginine and lysine methylation and demethylation, in the various aspects of liver disease, particularly in alcohol-associated liver disease, ALD and liver cirrhosis.
Lab Members
- Michael P. Schonfeld
- Sara Saleh
- Kruti Nataraj
- Mark Parrish
Open positions
- Postdoctoral fellow position
Graduate and undergraduate students are welcome to apply
Visit careers.kumc.edu >>
Left to right: Michael P. Schonfeld, Irina Tikhanovich, Kruti Nataraj, Mark ParrishReferences
Schonfeld M, Villar MT, Artigues A, Weinman SA, Tikhanovich I. Arginine Methylation of Integrin Alpha-4 Prevents Fibrosis Development in Alcohol-Associated Liver Disease. Cell Mol Gastroenterol Hepatol. 2023;15(1):39-59. doi: 10.1016/j.jcmgh.2022.09.013. Epub 2022 Sep 30. PubMed PMID: 36191854; PubMed Central PMCID: PMC9672451.
Schonfeld M, Averilla J, Gunewardena S, Weinman SA, Tikhanovich I. Alcohol-associated fibrosis in females is mediated by female-specific activation of lysine demethylases KDM5B and KDM5C. Hepatol Commun. 2022 Aug;6(8):2042-2057. doi: 10.1002/hep4.1967. Epub 2022 Apr 25. PubMed PMID: 35468265; PubMed Central PMCID: PMC9315128.
Schonfeld M, Averilla J, Gunewardena S, Weinman SA, Tikhanovich I. Male-Specific Activation of Lysine Demethylases 5B and 5C Mediates Alcohol-Induced Liver Injury and Hepatocyte Dedifferentiation. Hepatol Commun. 2022 Jun;6(6):1373-1391. doi: 10.1002/hep4.1895. Epub 2022 Jan 27. PubMed PMID: 35084807; PubMed Central PMCID: PMC9134811.
Schonfeld M, O'Neil M, Villar MT, Artigues A, Averilla J, Gunewardena S, Weinman SA, Tikhanovich I. A Western diet with alcohol in drinking water recapitulates features of alcohol-associated liver disease in mice. Alcohol Clin Exp Res. 2021 Oct;45(10):1980-1993. doi: 10.1111/acer.14700. Epub 2021 Sep 29. PubMed PMID: 34523155; PubMed Central PMCID: PMC9006178.
Schonfeld M, Villar MT, Artigues A, Weinman SA, Tikhanovich I. Arginine Methylation of Hepatic hnRNPH Suppresses Complement Activation and Systemic Inflammation in Alcohol-Fed Mice. Hepatol Commun. 2021 May;5(5):812-829. doi: 10.1002/hep4.1674. eCollection 2021 May. PubMed PMID: 34027271; PubMed Central PMCID: PMC8122385.
Zhao J, O'Neil M, Schonfeld M, Komatz A, Weinman SA, Tikhanovich I. Hepatocellular Protein Arginine Methyltransferase 1 Suppresses Alcohol-Induced Hepatocellular Carcinoma Formation by Inhibition of Inducible Nitric Oxide Synthase. Hepatol Commun. 2020 Jun;4(6):790-808. doi: 10.1002/hep4.1488. eCollection 2020 Jun. PubMed PMID: 32490317; PubMed Central PMCID: PMC7262284.
Schonfeld M, Zhao J, Komatz A, Weinman SA, Tikhanovich I. The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma. J Biol Chem. 2020 May 15;295(20):7126-7137. doi: 10.1074/jbc.RA120.013401. Epub 2020 Apr 3. PubMed PMID: 32245889; PubMed Central PMCID: PMC7242710.
Zhao J, Adams A, Weinman SA, Tikhanovich I. Hepatocyte PRMT1 protects from alcohol induced liver injury by modulating oxidative stress responses. Sci Rep. 2019 Jun 24;9(1):9111. doi: 10.1038/s41598-019-45585-2. PubMed PMID: 31235809; PubMed Central PMCID: PMC6591482.
Zhao J, O'Neil M, Vittal A, Weinman SA, Tikhanovich I. PRMT1-Dependent Macrophage IL-6 Production Is Required for Alcohol-Induced HCC Progression. Gene Expr. 2019 Apr 18;19(2):137-150. doi: 10.3727/105221618X15372014086197. Epub 2018 Sep 18. PubMed PMID: 30236171; PubMed Central PMCID: PMC6466176.
Zhao J, Adams A, Roberts B, O'Neil M, Vittal A, Schmitt T, Kumer S, Cox J, Li Z, Weinman SA, Tikhanovich I. Protein arginine methyl transferase 1- and Jumonji C domain-containing protein 6-dependent arginine methylation regulate hepatocyte nuclear factor 4 alpha expression and hepatocyte proliferation in mice. Hepatology. 2018 Mar;67(3):1109-1126. doi: 10.1002/hep.29587. Epub 2018 Jan 24. PubMed PMID: 29023917; PubMed Central PMCID: PMC5826837.