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Rajat S. Barua

Kansas City VA Faculty

Professional Background

Associate Professor of Medicine - Cardiology
Director, Cardiovascular Research, KCVA Med. Ctr.
Director, Interventional Cardiology & Cardiac Cath lab, KCVA Med. Ctr.
Nalanda Medical College, Patna, India
University of Surrey, United Kingdom
Residency, Mount Sinai School of Medicine (Internal Medicine)
Fellowship, UCSF School of Medicine (Cardiology) & Tufts University School of Medicine (Interventional)

Clinical Interests

  • Complex coronary intervention
  • Structural heart disease
  • Valvular heart disease
  • Percutaneous cardiovascular procedures

Research Interests

  • Endothelial function
  • Nitric oxide biology
  • Oxidative stress
  • Effect of testosterone in cardiovascular disease
  • Soluble bio-markers of cardiovascular dysfunction
  • Platelet fibrin interaction in coronary thrombosis
  • Angiogenesis
  • Cell therapy for cardiac repair

Selected Publications

  • Ambrose JA, Doss R, Geagea JP, Hawkey M, Duvuri S, Giedd K, Dominguez A, Coppola J, Nguyen TH, Palla V, Barua RS, Saha DC. Effects of the platelet glycoprotein IIb/IIIa inhibitors, abciximab versus tirofiban, on thrombin generation during percutaneous coronary intervention. Am J Cardiol. 2001;87:1231-3.
  • Saha DC, Barua RS, Astiz ME, Rackow EC, Eales-Reynolds L-J. Monophosphoryl lipid A stimulated up-regulation of reactive oxygen intermediates in human monocytes in vitro. J Leuko. Biol. 2001;70(3):381-85.
  • Barua RS, Ambrose JA, Eales-Reynolds L-J, De Voe MC, Zervas JG, Saha DC. Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilatation. Circulation. 2001;104:1905-1910.
  • Kirschenbaum LA, Adler D, Astiz ME, Barua RS, Saha DC, Rackow EC. Mechanism of platelet-neutrophil interactions and effects on cell filtration in septic shock. Shock. 2002;6:508-12.
  • Barua RS, Ambrose JA, Eales-Reynolds L-J, De Voe MC, Zervas JG, Saha DC. Heavy and light cigarette smokers have similar dysfunction of endothelial vasoregulatory activity: An in vivo and in vitro correlation. J Am Coll Cardiol. 2002;39:1758-63.
  • Barua RS, Ambrose JA, Reynolds L-J, Saha DC. Smoking is associated with altered endothelial-derived fibrinolytic and anti-thrombotic factors: An in vitro demonstration. Circulation. 2002;106:905-908.
  • Ambrose JA, Gould RB, Zairis MN, DeVoe MC, Nguyen TH, Geagea JP, Arias JH, Meraj P, Barua RS. Acute coronary lesions and troponin I elevation in unstable angina or non ST elevation acute myocardial infarction. Am J Cardiol. 2002;90:770-773.
  • Boulos M, Astiz ME, Barua RS, Osman M. Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly (ADP-ribose) synthase. Critical Care Medicine. 2003;31:353-8.
  • Puttappa D, Raia F, Bhat S, Braff R, Mandadi V, Barua RS, DeVoe MC, Boal BH, Ambrose JA. Peripheral left bundle block in patients with left ventricular dysfunction. Am J Cardiol. 2003;91:354-356.
  • Barua RS, Ambrose JA, Saha DC, Srivastava SK, DeVoe MC, L-J Eales-Reynolds. Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase in human coronary artery endothelial cells. Circulation. 2003;107:2342-47.
  • Mandadi VR, DeVoe MC, Ambrose JA, Prakash AM, Varshneya N, Gould RB, Nguyen TH, Geagea JP, Radojevic, Shehat K, Barua RS. Predictors of troponin elevation after percutaneous coronary intervention. Am J Cardiol. 2004;93:747-750.
  • Ambrose JA, Barua RS. The pathophysiology of smoking and cardiovascular disease: An update. (State of the art paper) J Am Coll Cardiol. 2004;43:1731-37.
  • Srikanth S, Barua R, Ambrose J. Methamphetamine-associated acute left ventricular dysfunction: a variant of stress-induced cardiomyopathy. Cardiology. 2008;109(3):188-92.
  • Javed U, Aftab W, Ambrose J, Mouanoutoua M, Wessel RJ, Huang G, Barua RS, Weilert M, Sy F, Thatai D. Frequency of Elevated Troponin-I and Diagnosis of Acute Myocardial Infarction. Am J Cardiol. 2009;104:9-13.
  • Barua RS, Sy F, Srikanth S , Javed U, Buhari C , Huang G, Margosan D, Ambrose JA. Effects of Cigarette Smoke Exposure on Clot Dynamics and Fibrin Structure. An Ex-Vivo Investigation. Arterioscler Thromb Vasc Biol. 2010;30:75-79.
  • Barua RS, Sy F, Srikanth S , Javed U, Buhari C , Huang G, Margosan D, Aftab W, Ambrose JA. Acute cigarette smoke exposure reduces clot lysis -- association between altered fibrin architecture and the response to t-PA. Thromb Res. 2010;126 :426-430.
  • Barua RS, Ambrose JA. Mechanisms of coronary thrombosis in cigarette smoke exposure. Arterioscler Thromb Vasc Biol. 2013; 33:1460-67.
  • Sharma R, Kamalakar S, McCarthy E,, Fields TA, Gupta K, Barua R. and Savin V. Proteinuria in Hypertensive Nephropathy: A Review. Open Journal of Nephrology 2014, 4, 92-99.
  • Masoomi R, Barua RS, Parashara DK. Spontaneous Hemopericardium with Dabigatran Etexilate. Journal of Cardiovascular Disease Research. 2015;6:179-81.
  • Sharma R, Oni OA, Gupta K, Chen G, Sharma M, Dawn B, Sharma R, Parashara D, Savin VJ, Ambrose JA, Barua RS. Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. Eur Heart J. 2015, 36:2706-15.
  • Barua RS, Sharma M, Dileepan, KN. Cigarette smoke amplifies inflammatory response and atherosclerosis progression through activation of the H1R-TLR2/4-COX2 axis. Front. Immunol. 2015, 6:572. doi: 10.3389/fimmu.2015.00572
  • Sharma R, Oni OA, Chen G, Sharma M, Dawn B, Sharma R, Parashara D, Savin VJ, Barua RS, Gupta K. Association between Testosterone Replacement Therapy and the Incidence of Deep Vein Thrombosis and Pulmonary Embolism: A Retrospective Cohort Study of the Veterans Administration Database. Chest 2016; 150:563-71.
  • Kamalakar S, Afzal MR, Barua RS , Parashara D. Epinephrine-Induced Takotsubo Cardiomyopathy Fed Pract. 2016 ;33(10)
  • Sharma R, Oni O, Gupta K, Sharma M, Sharma R, Singh V, Parashara D, Kamalakar S, Dawn B, Chen G, Ambrose JA, Barua RS. Normalization of Testosterone Levels after Testosterone Replacement Therapy is Associated with Decreased Incidence of Atrial Fibrillation. J Am Heart Assoc. 2017, 6(5). pii: e004880. doi: 10.1161/JAHA.116.004880.
  • Oni OA, Sharma R, Chen G, Sharma M, Gupta K, Dawn B, Sharma R, Parashara D, Savin VJ, Ambrose JA, Barua RS. Normalization of Testosterone Level is Not Associated with Reduced Myocardial Infarction in Smokers. Mayo Clin Proc Inn Qual Out. 2017;1:57-66.

KU School of Medicine

University of Kansas Medical Center
Cardiovascular Medicine
3901 Rainbow Boulevard
Mailstop 4023
Kansas City, KS 66160