Ram Thiyagarajan, Ph.D.

Professional Background

I am focused on unraveling the molecular underpinnings (transcriptomics, proteomics, and metabolomics) of the interactions between immunosenescence (myeloid cells) and neuroinflammation (microglia) and identifying putative diagnostic and prognostic biomarkers for aging, age-related dementia. In addition, I am interested in understanding the interactions of mRNA and miRNA during inflammaging and understanding the role of RNA-binding proteins in age-related neuroinflammation.

• BS, Biochemistry, University of Madras, India
• MS, Medical Physiology, University of Madras, India
• PhD, Medical Physiology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), India
• Other, Biochemistry, University of Buffalo, Buffalo, NY
• Post Doctoral Fellowship, Department of Medicine, Division of Geriatrics and Palliative Medicine, University of Buffalo, Buffalo, NY

• Rajabian, Nika, Ikhapoh, Izuagie, Shahini, Shahryar, Choudhury, Debanik, Thiyagarajan, Ramkumar, Shahini, Aref, Kulczyk, Joseph, Breed, Kendall, Saha, Shilpashree, Mohamed, Mohamed., Alaa, Udin, Susan., B., Stablewski, Aimee, Seldeen, Kenneth, Troen, Bruce., R., Personius, Kirkwood, Andreadis, Stelios., T.. 2023. Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle. Nature Communications, 14 (1). https://doi.org/10.1038/s41467-023-36483-3
• Kwack, Kyu., Hwan, Zhang, Lixia, Kramer, Elliot., D., Thiyagarajan, Ramkumar, Lamb, Natalie., A., Arao, Yukitomo, Bard, Jonathan., E., Seldeen, Kenneth., L., Troen, Bruce., R., Blackshear, Perry., J., Abrams, Scott., I., Kirkwood, Keith., L.. 2022. Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1002163
• Choudhury, Debanik, Rong, Na, Ikhapoh, Izuagie, Rajabian, Nika, Tseropoulos, Georgios, Wu, Yulun, Mehrotra, Pihu, Thiyagarajan, Ramkumar, Shahini, Aref, Seldeen, Kenneth., L., Troen, Bruce., R., Lei, Pedro, Andreadis, Stelios., T.. 2022. Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells. Cell Reports, 41 (9), 111744. https://doi.org/10.1016/j.celrep.2022.111744
• Shahini, Aref, Rajabian, Nika, Choudhury, Debanik, Shahini, Shahryar, Vydiam, Kalyan, Nguyen, Thy, Kulczyk, Joseph, Santarelli, Tyler, Ikhapoh, Izuagie, Zhang, Yali, Wang, Jianmin, Liu, Song, Stablewski, Aimee, Thiyagarajan, Ramkumar, Seldeen, Kenneth, Troen, Bruce., R., Peirick, Jennifer, Lei, Pedro, Andreadis, Stelios., T.. 2021. Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo. Science Advances, 7 (36). https://doi.org/10.1126/sciadv.abe5671
• Seldeen, Kenneth., Ladd, Shahini, Aref, Thiyagarajan, Ramkumar, Redae, Yonas, Leiker, Merced, Rajabian, Nika, Dynka, Andrew, Andreadis, Stelios., T., Troen, Bruce., Robert. 2021. Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors. Nutrition, 87-88, 111189. https://doi.org/10.1016/j.nut.2021.111189
• Seldeen, Kenneth., Ladd, Redae, Yonas., Z., Thiyagarajan, Ramkumar, Berman, Reem., Nagi, Leiker, Merced., Marie, Troen, Bruce., Robert. 2019. High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools. Mechanisms of Ageing and Development, 180, 49-62. https://doi.org/10.1016/j.mad.2019.04.001
• Kirkwood, Keith., L., Zhang, Lixia, Thiyagarajan, Ramkumar, Seldeen, Kenneth., L., Troen, Bruce., R.. 2018. Myeloid-Derived Suppressor Cells at the Intersection of Inflammaging and Bone Fragility. Immunological Investigations, 47 (8), 844-854. https://doi.org/10.1080/08820139.2018.1552360
• Thiyagarajan, Ramkumar, Pal, Pravati, Pal, Gopal., Krushna, Subramanian, Senthil., Kumar, Trakroo, Madanmohan, Bobby, Zachariah, Das, Ashok., Kumar. 2015. Additional benefit of yoga to standard lifestyle modification on blood pressure in prehypertensive subjects: a randomized controlled study. Hypertension Research, 38 (1), 48-55. https://doi.org/10.1038/hr.2014.126
• Thiyagarajan, Ramkumar, Pal, Pravati, Pal, Gopal., Krushna, Subramanian, Senthil., Kumar, Bobby, Zachariah, Das, Ashok., Kumar, Trakroo, Madanmohan. 2013. Cardiovagal modulation, oxidative stress, and cardiovascular risk factors in prehypertensive subjects: cross-sectional study. American journal of hypertension, 26 (7), 850--857
• Thiyagarajan, Ramkumar, Subramanian, Senthil., Kumar, Sampath, Nishanth, Madanmohan Trakroo, Pal, Pravati, Bobby, Zachariah, Paneerselvam, Sankar, Das, Ashok., Kumar, Manco, Melania. 2012. Association between Cardiac Autonomic Function, Oxidative Stress and Inflammatory Response in Impaired Fasting Glucose Subjects: Cross-Sectional Study. PLoS ONE, 7 (7), e41889. https://doi.org/10.1371/journal.pone.0041889