Ram Thiyagarajan, Ph.D.

Professional Background

I am focused on unraveling the molecular underpinnings (transcriptomics, proteomics, and metabolomics) of the interactions between immunosenescence (myeloid cells) and neuroinflammation (microglia) and identifying putative diagnostic and prognostic biomarkers for aging, age-related dementia. In addition, I am interested in understanding the interactions of mRNA and miRNA during inflammaging and understanding the role of RNA-binding proteins in age-related neuroinflammation.

• BS, Biochemistry, University of Madras, India
• MS, Medical Physiology, University of Madras, India
• PhD, Medical Physiology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), India
• Other, Biochemistry, University of Buffalo, Buffalo, NY
• Post Doctoral Fellowship, Department of Medicine, Division of Geriatrics and Palliative Medicine, University of Buffalo, Buffalo, NY

• Rajabian Nika, Ikhapoh Izuagie, Shahini Shahryar, Choudhury Debanik, Thiyagarajan Ramkumar, Shahini Aref, Kulczyk Joseph, Breed Kendall, Saha Shilpashree, Mohamed MohamedAlaa, Udin SusanB., Stablewski Aimee, Seldeen Kenneth, Troen BruceR., Personius Kirkwood, Andreadis SteliosT.. 2023. Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle. Nature Communications, 14 (1). https://doi.org/10.1038/s41467-023-36483-3
• Kwack KyuHwan, Zhang Lixia, Kramer ElliotD., Thiyagarajan Ramkumar, Lamb NatalieA., Arao Yukitomo, Bard JonathanE., Seldeen KennethL., Troen BruceR., Blackshear PerryJ., Abrams ScottI., Kirkwood KeithL.. 2022. Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1002163
• Choudhury Debanik, Rong Na, Ikhapoh Izuagie, Rajabian Nika, Tseropoulos Georgios, Wu Yulun, Mehrotra Pihu, Thiyagarajan Ramkumar, Shahini Aref, Seldeen KennethL., Troen BruceR., Lei Pedro, Andreadis SteliosT.. 2022. Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells. Cell Reports, 41 (9), 111744. https://doi.org/10.1016/j.celrep.2022.111744
• Shahini Aref, Rajabian Nika, Choudhury Debanik, Shahini Shahryar, Vydiam Kalyan, Nguyen Thy, Kulczyk Joseph, Santarelli Tyler, Ikhapoh Izuagie, Zhang Yali, Wang Jianmin, Liu Song, Stablewski Aimee, Thiyagarajan Ramkumar, Seldeen Kenneth, Troen BruceR., Peirick Jennifer, Lei Pedro, Andreadis SteliosT.. 2021. Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo. Science Advances, 7 (36). https://doi.org/10.1126/sciadv.abe5671
• Seldeen KennethLadd, Shahini Aref, Thiyagarajan Ramkumar, Redae Yonas, Leiker Merced, Rajabian Nika, Dynka Andrew, Andreadis SteliosT., Troen BruceRobert. 2021. Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors. Nutrition, 87-88, 111189. https://doi.org/10.1016/j.nut.2021.111189
• Seldeen KennethLadd, Redae YonasZ., Thiyagarajan Ramkumar, Berman ReemNagi, Leiker MercedMarie, Troen BruceRobert. 2019. High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools. Mechanisms of Ageing and Development, 180, 49-62. https://doi.org/10.1016/j.mad.2019.04.001
• Kirkwood KeithL., Zhang Lixia, Thiyagarajan Ramkumar, Seldeen KennethL., Troen BruceR.. 2018. Myeloid-Derived Suppressor Cells at the Intersection of Inflammaging and Bone Fragility. Immunological Investigations, 47 (8), 844-854. https://doi.org/10.1080/08820139.2018.1552360
• Thiyagarajan Ramkumar, Pal Pravati, Pal GopalKrushna, Subramanian SenthilKumar, Trakroo Madanmohan, Bobby Zachariah, Das AshokKumar. 2015. Additional benefit of yoga to standard lifestyle modification on blood pressure in prehypertensive subjects: a randomized controlled study. Hypertension Research, 38 (1), 48-55. https://doi.org/10.1038/hr.2014.126
• Thiyagarajan Ramkumar, Pal Pravati, Pal GopalKrushna, Subramanian SenthilKumar, Bobby Zachariah, Das AshokKumar, Trakroo Madanmohan. 2013. Cardiovagal modulation, oxidative stress, and cardiovascular risk factors in prehypertensive subjects: cross-sectional study. American journal of hypertension, 26 (7), 850--857
• Thiyagarajan Ramkumar, Subramanian SenthilKumar, Sampath Nishanth, Madanmohan Trakroo, Pal Pravati, Bobby Zachariah, Paneerselvam Sankar, Das AshokKumar, Manco Melania. 2012. Association between Cardiac Autonomic Function, Oxidative Stress and Inflammatory Response in Impaired Fasting Glucose Subjects: Cross-Sectional Study. PLoS ONE, 7 (7), e41889. https://doi.org/10.1371/journal.pone.0041889