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Ramkumar Thiyagarajan, Ph.D.

Ramkumar Thiyagarajan portrait
Assistant Professor, Geriatric Medicine

Distinguished Adjunct Faculty, Saveetha Institute of Medical and Technical Sciences

rthiyagarajan@kumc.edu

Professional Background

I am focused on unraveling the molecular underpinnings (transcriptomics, proteomics, and metabolomics) of the interactions between immunosenescence (myeloid cells) and neuroinflammation (microglia) and identifying putative diagnostic and prognostic biomarkers for aging, age-related dementia. In addition, I am interested in understanding the interactions of mRNA and miRNA during inflammaging and understanding the role of RNA-binding proteins in age-related neuroinflammation.

Education and Training
  • BS, Biochemistry, University of Madras, India
  • MS, Medical Physiology, University of Madras, India
  • PhD, Medical Physiology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), India
  • Other, Biochemistry, University of Buffalo, Buffalo, NY
  • Post Doctoral Fellowship, Department of Medicine, Division of Geriatrics and Palliative Medicine, University of Buffalo, Buffalo, NY

Publications
  • Rajabian, Nika, Ikhapoh, Izuagie, Shahini, Shahryar, Choudhury, Debanik, Thiyagarajan, Ramkumar, Shahini, Aref, Kulczyk, Joseph, Breed, Kendall, Saha, Shilpashree, Mohamed, Mohamed., Alaa, others. 2023. Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle. Nature Communications, 14 (1), 886
  • Kwack, Kyu., Hwan, Zhang, Lixia, Kramer, Elliot., D, Thiyagarajan, Ramkumar, Lamb, Natalie., A, Arao, Yukitomo, Bard, Jonathan., E, Seldeen, Kenneth., L, Troen, Bruce., R, Blackshear, Perry., J, others. 2022. Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells. Frontiers in Immunology, 13
  • Choudhury, Debanik, Rong, Na, Ikhapoh, Izuagie, Rajabian, Nika, Tseropoulos, Georgios, Wu, Yulun, Mehrotra, Pihu, Thiyagarajan, Ramkumar, Shahini, Aref, Seldeen, Kenneth., L, others. 2022. Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells. Cell reports, 41 (9), 111744
  • Shahini, Aref, Rajabian, Nika, Choudhury, Debanik, Shahini, Shahryar, Vydiam, Kalyan, Nguyen, Thy, Kulczyk, Joseph, Santarelli, Tyler, Ikhapoh, Izuagie, Zhang, Yali, others. 2021. Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo. Science Advances, 7 (36), eabe5671
  • Seldeen, Kenneth., Ladd, Shahini, Aref, Thiyagarajan, Ramkumar, Redae, Yonas, Leiker, Merced, Rajabian, Nika, Dynka, Andrew, Andreadis, Stelios., T, Troen, Bruce., Robert. 2021. Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors. Nutrition, 87, 111189
  • Seldeen, Kenneth., Ladd, Redae, Yonas., Z, Thiyagarajan, Ramkumar, Berman, Reem., Nagi, Leiker, Merced., Marie, Troen, Bruce., Robert. 2019. High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools. Mechanisms of ageing and development, 180, 49--62
  • Kirkwood, Keith., L, Zhang, Lixia, Thiyagarajan, Ramkumar, Seldeen, Kenneth., L, Troen, Bruce., R. 2018. Myeloid-derived suppressor cells at the intersection of inflammaging and bone fragility. Immunological investigations, 47 (8), 844--854
  • Thiyagarajan, Ramkumar, Pal, Pravati, Pal, Gopal., Krushna, Subramanian, Senthil., Kumar, Trakroo, Madanmohan, Bobby, Zachariah, Das, Ashok., Kumar. 2015. Additional benefit of yoga to standard lifestyle modification on blood pressure in prehypertensive subjects: a randomized controlled study. Hypertension Research, 38 (1), 48--55
  • Thiyagarajan, Ramkumar, Pal, Pravati, Pal, Gopal., Krushna, Subramanian, Senthil., Kumar, Bobby, Zachariah, Das, Ashok., Kumar, Trakroo, Madanmohan. 2013. Cardiovagal modulation, oxidative stress, and cardiovascular risk factors in prehypertensive subjects: cross-sectional study. American journal of hypertension, 26 (7), 850--857
  • Thiyagarajan, Ramkumar, Subramanian, Senthil., Kumar, Sampath, Nishanth, Trakroo, Madanmohan, Pal, Pravati, Bobby, Zachariah, Paneerselvam, Sankar, Das, Ashok., Kumar. 2012. Association between cardiac autonomic function, oxidative stress and inflammatory response in impaired fasting glucose subjects: cross-sectional study