Research

Clinical Trials

The following clinical trials are currently recruiting participants. If you would like more information regarding the trial or how to participate, please contact the study coordinator or complete the Nephrology Clinical Research Interest Form and we will contact you.

Trial Name	Sponsor	Summary	Details	Study Coordinator
FIND-CKD	Bayer	Phase 3 Trial to Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease (FIND-CKD).	Participants will take finerenone or a placebo once a day as tablets by mouth for a period of 32 months.	Debbie Griffin Elisabeth Laundy
Neptune	National Institutes of Health, NIDDK, Nephcure Kidney International, University of Michigan	The purpose of this multi-center, observational research study is to learn more about four diseases which cause nephrotic syndrome: Focal Segmental Glomerulosclerosis (FSGS), Minimal Change Disease (MCD), and Membranous Nephropathy (MN) and Alport syndrome. By collecting health information and laboratory samples from individuals who have these diseases and by making this information available to researchers, we hope to gain new knowledge about these diseases and to find better treatments for them.	Length: Participation lasts for 3 years. During the first year, there are 4 study visits. There are two study visits in year 2 and in year 3. When possible, study visits are scheduled to coincide with regularly scheduled clinic appointments. Time commitment: approximately one hour per visit. Patients are seen at enrollment and at 4-6 month intervals. Visits are in-person and by telephone. When possible, study visits are scheduled to coincide with regularly scheduled clinic appointments. Procedures: Blood and urine samples, kidney tissue (only if a biopsy is already being done) and various types of information are obtained from participants. Biospecimens are stored in biorepositories and are made available to researchers for approved research studies. Eligibility: age 18 - 79, patients with Focal Segmental Glomerulosclerosis (FSGS), Minimal Change Disease, Membranous Nephropathy and Alport syndrome may be eligible	Cathy Creed Elisabeth Laundy
Cognitive Impairment	KUMC Kidney Institute	Evaluation of the changes in memory and thinking before and after transplant in relation to changes seen in images of the brain	Length: 1-2 years Time commitment: 1-2 visits pre-transplant, and 2 visits prost-transplant to complete assessments Procedures: Memory assessments, brain MRI, collection of blood and urine, medical history, and questionnaires Eligibility: age 25-70, pre-transplant ESRD patients listed for renal transplantation at KU	Sean Obrien Jessica Wilson
EPOC PKD	NIH	This observational study will collect blood and urine and clinical information from individuals with early-stages of polycystic kidney disease (PKD), The long-term goal is to develop new knowledge of biomarkers that indicate changes in the disease progression. An understanding of biomarkers will benefit PKD patients as new therapies are being developed and tested.	Length: 5 years Time commitment: Two hours once per year Procedures: MRI, blood and urine labs, and questionnaires Eligibility: age 4-35, with early stage PKD, and normal kidney function	Cathy Creed Elisabeth Laundy Debbie Griffin
FALCON	REATA	FALCON is a Phase 3 clinical study evaluating the effectiveness and safety of bardoxolone methyl (an oral investigational drug) in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).	Length: 2 years ime commitment: 24 visits over 2 years, each visit is one to two hours in length Procedures: EKG, Echocardiogram, physical exams, collection of blood and urine, medical history, and questionnaires Eligibility: age 18 - 69	Cathy Creed Elisabeth Laundy Debbie Griffin
Fabry Registry	Genzyme	Collection of clinical data on patients with Fabry disease around the world in an effort to help health professionals involved in treatment or diagnosis better understand Fabry Disease and its management	Length: Indefinitely Time commitment: Data will be obtained from medical record. 30 minutes or less phone call if additional information needed Procedures: Questionnaires Eligibility: Diagnosed with Fabry Disease	Debbie Griffin
Renal Tubular Function in Living Donors	Investigator initiated	Evaluate the renal tubular function pre- and post-nephrectomy in living donors.	The study will help to better understand the long-term effects of loss of nephrons on tubular function and injury in otherwise healthy humans. This will be a prospective trial where living donors will have renal function and tubular function checked before nephrectomy and at one year post-nephrectomy.	Sean Obrien Jessica Wilson
Cognitive Function-Everolimus	Novartis, llT	Title: Alterations in Cognitive Function and Cerebral Blood Flow after Conversion from Calcineurin Inhibitors to Everolimus. This single center longitudinal 12 weeks observational study will determine whether conversion from calcineurin inhibitor (Tacrolimus) to an mTOR inhibitor, Everolimus, is associated with improvement in cognition and cerebral blood flow.	Goal: Enroll 20 kidney transplant recipients who will undergo conversion and 10 matched controls at the University of Kansas Medical Center.	Sean Obrien Jessica Wilson
PKD Registry	KUMC Jared Grantham Kidney Institute	The University of Kansas Medical Center is establishing a biorepository of blood and urine samples from adults with Polycystic Kidney Disease (PKD) in order to provide specimens to investigators for the discovery of biomarkers. Biomarkers may help monitor PKD progression and determine the effectiveness of new treatments	Length: One Visit Only Time commitment: One Hour Procedures: fasting blood and urine collection, blood pressure, medical history questionnaire Eligibility: diagnosed with PKD, age 18 – 70, have had an MRI or CT scan within the last 5 years	Cathy Creed Casey Tan

Study Coordinator Contact Information

Cathy Creed, RN
ccreed@kumc.edu
(913) 588-0053

Sean Obrien
sobrien5@kumc.edu
(913) 574-0895

Jessica Wilson
jwilson12@kumc.edu
(913) 574-0894

Debbie Griffin, RN, CDE
dgriffin3@kumc.edu
(913) 588-7691

Elisabeth Laundy
elaundy@kumc.edu
(913) 588-8983

Casey Tan
ctan2@kumc.edu
(913) 574-3255

Nephrology Clinical Research Interest Form