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COBRE Overview

Welcome to the website for our Center for Biomedical Research Excellece (COBRE) Grant entitled Novel Approaches for Control of Microbial Pathogens. 

PI:  Joe Lutkenhaus, Ph.D.

Our COBRE was first funded in 2001 and then renewed in 2006. Our Phase III application was awarded in 2012.  The objective of the center is to promote and to enhance the research capabilities of tenure track junior faculty members of participating institutions in the state of Kansas with emphasis on inhibiting microbial pathogens. The program has been highly successful during the first ten years with the awarding of 34 Project and faculty enhancement awards. At the end of Phase II, 34 tenure track faculty had received awards and investigators supported by COBRE had obtained 46 NIH grants resulting in a total of over $40 million in new funding for the state of Kansas.

Additional areas that our COBRE supports include the Flow Cytometry Core Laboratory and a Seminar Series.

The first two phases of this grant were made possible by NIH Grant Number P20 RR016443 from the COBRE program of the National Center for Research Resources.   Phase III is made possible by NIH Grant Number P30 GM103326 from the COBRE program of the National Institute of General Medical Sciences.

Congratulations to our Year 1 Pilot Project Recipients 

  • David Davido, Ph.D., University of Kansas
    HSV-1-mediated proteolysis of cellular targets
  • Revathi Govind, Ph.D., Kansas State University
    Role of TcdR, the alternate sigma factor in Clostridium difficile virulence
  • Jianming Qiu, Ph.D., University of Kansas Medical Center
    Mechanisms of the cell cycle arrest induced during parvovirus B19 infection
  • Wolfram Zueckert, Ph.D., University of Kansas Medical Center
    Mechanism of Borrelia Surface Lipoprotein Secretion

Congratulations to our Year 2 Pilot Project Recipients

  • Bhaskar Das, Ph.D., University of Kansas Medical Center
    Edward Stephens, Ph.D., University of Kansas Medical Center
    Nanoparticle conjugated retinoids as effective therapeutic agents against HIV-infection
  • Susan Egan, Ph.D., University of Kansas
    Inhibitors of AraC family virulence activators in Enterotoxigenic E. coli and Shigella

Congratulations to our Year 3 Pilot Project Recipients

  • David Davido, Ph.D., University of Kansas
    Viral and host factors regulate HSV-1 infection
  • Steven LeVine, Ph.D., University of Kansas Medical Center
    Genetic Modifiers of Sepsis

Congratulations to our Year 4 Pilot Project Recipients

  • Jeffrey Bose, Ph.D., University of Kansas Medical Center
    Alternate mechanisms behind AtlA-dependent biofilm formation in S. aureus
  • Mary Markiewicz, Ph.D., University of Kansas Medical Center
    The role of NKG2D in immunosurveillance of spontaneous lymphoma
  • Jianming Qiu, Ph.D., University of Kansas Medical Center
    Airway Epithelium Response to Parvovirus Infection

 Questions or Comments - Please contact Elizabeth Jenkins