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Policy & Organizational factors that Affect the Utilization of Health Services for Alzheimer's Disease Among the Latino Community - The Primary Care Provider Perspective
CONCLUSION: Economic and organizational factors, including insurance, costs, staffing models, and resource navigation, shape PCPs' ability to deliver culturally competent and equitable ADRD care. Future interventions should address these barriers by training PCPs in diagnostic procedures in Latino communities and developing accessible service models and culturally appropriate diagnostic tools.
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Scaling Alzheimer's Care: The Case for Specialized Treatment Clinics
CONCLUSIONS: Our findings suggest that a specialized clinic structure can support safe, accessible, and efficient care for AD patients, potentially serving as a scalable model for healthcare systems adapting to the demands of emerging AD treatments. Expanding similar clinics may address neurologist shortages and improve equitable access to advanced therapies.
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The striatum is an early, accurate indicator of amyloid burden using [<sup>11</sup>C]PiB in Down syndrome: Comparison of two radiotracers
INTRODUCTION: Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [^(11)C]Pittsburgh Compound-B (PiB) positron emission tomography (PET) imaging, which has not been replicated with [^(18)F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.
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Prevalence of Reported Dietary Supplement Use in 2019 Older Adult (≥ 55 Years) National Alzheimer's Coordinating Center Participants With Normal Cognition, Mild Cognitive Impairment or Dementia
CONCLUSION: For many DSs, prevalence was significantly lower in dementia compared to NC. Reported use of any DS was highly prevalent in NACC older adults with NC, MCI or dementia in 2019.
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A head-to-head comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials
Adults with Down syndrome carry high risk of developing Alzheimer's disease and efforts to include this population in clinical trials remain limited. A barrier to recruitment for anti-amyloid trials includes the availability of the same amyloid PET radiotracer to multiple treatment centers. 237 adults with Down syndrome from the Trial-Ready Cohort - Down syndrome and Alzheimer Biomarker Consortium - Down syndrome studies were imaged using T1-w MRI and using PET images of PiB, Florbetapir (FBP),...
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AI-driven fusion of neurological work-up for assessment of biological Alzheimer's disease
Alzheimer's disease (AD) diagnosis hinges on detecting amyloid beta (A β ) plaques and neurofibrillary tau ( τ ) tangles. While amyloid PET imaging is now clinically approved, tau PET remains largely restricted to research settings. These imaging techniques, though valuable, are expensive and often difficult to access, limiting their widespread use in routine clinical practice. Here, we introduce a computational framework that leverages multimodal data from seven distinct cohorts comprising 12,...
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Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort
INTRODUCTION: Amyloid positron emission tomography (PET) is increasingly available for diagnosis of Alzheimer`s disease (AD); however, its practical implications in heterogenous cohorts are debated.
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Motor symptoms in autopsy-confirmed Alzheimer's disease increase the risk of progression to severe cognitive impairment
INTRODUCTION: Motor symptoms may present throughout the Alzheimer's disease (AD) course. We evaluated the impact of motor symptoms on the risk of progression to severe cognitive impairment, severe neuropsychiatric symptoms (NPSs), and mortality in patients with autopsy-confirmed AD. We also examined the rates of non-AD pathology and identified the predictors of disease progression among these patients.
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APOE4 Exerts Partial Diet-dependent Effects on Energy Expenditure and Skeletal Muscle Mitochondrial Pathways in a Preclinical Model
Apolipoprotein E4 (APOE4) is the greatest genetic risk factor for Alzheimer's (AD) and is linked to whole-body metabolic dysfunction. However, it is unclear how APOE4 interacts with modifiable factors like diet to impact tissues central to regulating whole-body metabolism. We examined APOE4- and Western diet-driven effects in skeletal muscle using APOE3 (control) and APOE4 targeted replacement mice on a C57BL/6NTac background fed a high-fat diet (HFD, 45% kcal fat) or low-fat diet (LFD, 10% kcal...
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Marital status and risk of dementia over 18 years: Surprising findings from the National Alzheimer's Coordinating Center
INTRODUCTION: Marital status is a potential risk/protective factor for adverse health outcomes. This study tested whether marital status was associated with dementia risk in older adults.
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The impact of arteriolosclerosis on cognitive impairment in decedents without severe dementia from the National Alzheimer's Coordinating Center
INTRODUCTION: Alzheimer's disease neuropathologic change (ADNC), Lewy body disease (LBD), and vascular neuropathologies occur together. Previous studies have been limited by a large majority of participants with severe dementia or advanced stages of pathologies, which limits the detectability of cognitive effects from vascular neuropathologies.
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Distinct medical and substance use histories associate with cognitive decline in Alzheimer's disease
INTRODUCTION: Phenotype clustering reduces patient heterogeneity and could be useful when designing precision clinical trials. We hypothesized that the onset of early cognitive decline in patients would exhibit variance predicated on the clinical history documented prior to an Alzheimer's disease (AD) diagnosis.
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Blood biomarkers differentiate AD-related versus non-AD-related cognitive deficits
INTRODUCTION: The utility of blood-based biomarkers for discriminating Alzheimer's disease (AD)-related versus non-AD-related cognitive deficits in preclinical populations remains poorly understood. Here, we tested the capability of blood markers to detect and discriminate variation in performance across multiple cognitive domains in a cognitively unimpaired sample.
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Regularization by Neural Style Transfer for MRI Field-Transfer Reconstruction with Limited Data
Recent advances in MRI reconstruction have demonstrated remarkable success through deep learning-based models. However, most existing methods rely heavily on large-scale, task-specific datasets, making reconstruction in data-limited settings a critical yet underexplored challenge. While regularization by denoising (RED) leverages denoisers as priors for reconstruction, we propose Regularization by Neural Style Transfer (RNST), a novel framework that integrates a neural style transfer (NST)...
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A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions
Serine/Threonine phosphoprotein phosphatases (PPPs, PP1-PP7) are conserved metalloenzymes and central to intracellular signaling in eukaryotes, but the details of their regulation is poorly understood. To address this, we performed genome-wide CRISPR knockout and focused base editor screens in PPP perturbed conditions to establish a high-resolution functional map of PPP regulation that pinpoints novel regulatory mechanisms. Through this, we identify the orphan reductase CYB5R4 as an...