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Matthew R. Sharpe, M.D.

Matthew Sharpe portrait
Associate Professor, Pulmonary, Critical Care and Sleep Medicine

Professional Background

Dr. Matthew Sharpe is an Associate Professor of Medicine at the University of Kansas Medical Center. Dr. Sharpe received his medical degree from the University of Kansas School of Medicine and proceeded to complete Medicine-Pediatrics residency, chief residency, and Adult Pulmonary and Critical Care fellowship at the University of Kansas Medical Center. His clinical and scholarly interests include severe asthma, pulmonary and critical care medicine and graduate medical education. He is medical director for the Allied Health Respiratory Care program at the University of Kansas School of Medicine and sits on the Board of Medical Advisors for the American Association of Respiratory Care. He is the clinical clerkship director for 4th year medical students rotating through the medical intensive care unit and a phase II representative for Education Council. Dr. Sharpe is an active participant in medical education curriculum and simulation development.

Dr. Sharpe strives to provide advanced, comprehensive and compassionate care to all patients living with asthma through excellence in teaching, research and patient care. He focuses on the importance of asthma education for the patient and provides exceptional medical education to students, residents and other health professionals. He is committed to providing world class clinical services to the community and throughout the State of Kansas while remaining dedicated to innovative research to expand the frontiers of medical knowledge.

Education and Training
  • BA, ., University of Kansas, Lawrence, Kansas
  • MD, Medicine, University of Kansas Medical Center, Kansas City, KS
  • Residency, Medicine-Pediatrics, University of Kansas Hospital, Kansas City, KS
  • Clinical Fellowship, Pulmonary-Critical Care, University of Kansas Hospital, Kansas City, KS
Licensure, Accreditations & Certifications
  • American Board of Critical Care Medicine Maintenance of Certification Examination, American Board of Internal Medicine
  • American Board of Pulmonary Medicine Maintenance of Certification Examination, American Board of Internal Medicine
  • Doctor of Medicine, Kansas State Board of Healing Arts
Professional Affiliations
  • American College of Chest Physicians, Member, 2021 - Present
  • American Thoracic Society, Member, 2021 - Present



Dr. Sharpe's research interests focus on medical education and asthma. His work includes development of a fourth-year medical student simulation curriculum and simulated central line project with medical residents. He was co-investigator on a simulated medical student experience where students follow a patient over their 4 years of study as the patient progresses through a chronic and ultimately terminal disease.

He has built collaborations with the department of basic sciences on translational work involving patients with Tylenol-induced liver failure. This group was one of the first to look at the mechanism underlying acetaminophen-induced hepatotoxicity in humans. Their findings were published in the well-respected Journal of Clinical Investigation in 2012.

Currently, Dr. Sharpe's asthma interests have moved more toward active participation at the community education level. He is excited to engage with the communities of Kansas City and work to reduce uncontrolled asthma rates. In addition, he plans to work with National (CMS), State and local agencies on the development of a State of Kansas Asthma Initiative. In collaboration with our allied health partners in respiratory care, I hope to develop a virtual asthma educational platform that can be used to educate health care providers in rural Kansas.

  • Antoine, D., J, Jenkins, R., E, Dear, J., W, Williams, D., P, McGill, M., R, Sharpe, M., R, Craig, D., G, Simpson, K., J, Jaeschke, H, Park, B., K. 2020. Retraction notice to "Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity": J Hepatol 56(2012)1070-1079.. Journal of hepatology, 73 (5), 1297
  • Ellerbeck, E., F, Nollen, N, Hutcheson, T., D, Phadnis, M, Fitzgerald, S., A, Vacek, J, Sharpe, M., R, Salzman, G., A, Richter, K., P. 2018. Effect of Long-term Nicotine Replacement Therapy vs Standard Smoking Cessation for Smokers With Chronic Lung Disease: A Randomized Clinical Trial.. JAMA network open, 1 (5), e181843. doi:10.1001/jamanetworkopen.2018.1843
  • Weemhoff, J., L, Woolbright, B., L, Jenkins, R., E, McGill, M., R, Sharpe, M., R, Olson, J., C, Antoine, D., J, Curry, S., C, Jaeschke, H. 2017. Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis.. Liver international : official journal of the International Association for the Study of the Liver, 37 (3), 377-384.
  • Burnett, D., M, Vardiman, J., P, Deckert, J., A, Ward, J., L, Sharpe, M., R. 2016. Perception of Exercise-Induced Bronchoconstriction in College Athletes.. Respiratory care, 61 (7), 897-901.
  • Xie, Y, McGill, M., R, Cook, S., F, Sharpe, M., R, Winefield, R., D, Wilkins, D., G, Rollins, D., E, Jaeschke, H. 2015. Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.. Xenobiotica; the fate of foreign compounds in biological systems, 45 (10), 921-9.
  • Diederich, E, Mahnken, J., D, Rigler, S., K, Williamson, T., L, Tarver, S, Sharpe, M., R. 2015. The Effect of Model Fidelity on Learning Outcomes of a Simulation-Based Education Program for Central Venous Catheter Insertion.. Simulation in healthcare : journal of the Society for Simulation in Healthcare, 10 (6), 360-367.
  • Woolbright, B., L, McGill, M., R, Staggs, V., S, Winefield, R., D, Gholami, P, Olyaee, M, Sharpe, M., R, Curry, S., C, Lee, W., M, Jaeschke, H. 2014. Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients.. Toxicological sciences : an official journal of the Society of Toxicology, 142 (2), 436-44.
  • Williams, C., D, Bajt, M., L, Sharpe, M., R, McGill, M., R, Farhood, A, Jaeschke, H. 2014. Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.. Toxicology and applied pharmacology, 275 (2), 122-33.
  • McGill, M., R, Staggs, V., S, Sharpe, M., R, Lee, W., M, Jaeschke, H. 2014. Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome.. Hepatology (Baltimore, Md.), 60 (4), 1336-45.
  • McGill, M., R, Li , F, Sharpe, M., R, Williams, C., D, Curry, S., C, Ma, X, Jaeschke, H. 2014. Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.. Archives of toxicology, 88 (2), 391-401.