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Lejla Zubcevic, Ph.D.

Lejla Zubcevic portrait
Assistant Professor, Biochemistry and Molecular Biology
lzubcevic@kumc.edu

Professional Background

University of Oxford, Oxford, UK. D.Phil student. Department of Condensed Matter Physics, 2008-2013
Duke University, Durham, North Carolina. Postdoctoral Research Associate, Department of Biochemistry, 2013 - 2019

Interests: Transport across biological membranes, ion channels, biophysics, membrane protein biochemistry, X-ray crystallography, single particle cryo-EM

Education and Training
  • BSc, Biochemistry, University of Copenhagen, Copenhagen, Denmark
  • MSC, Pharmacology, University of Oxford, Oxford, England
  • PhD, Biophysics, University of Oxford, Oxford, England
  • Post Doctoral Fellowship, Ion channels, Structural biology, Duke University, Durham, NC

Research

Overview

Research Interests

The Zubcevic lab is interested in elucidating the molecular mechanisms of transport across biological membranes. We use single particle cryo-EM and X-ray crystallography to study mammalian ion channels and transporters.

Current Research and Grants
  • Mechanistic studies of magnesium transport, Klingenstein-Simons Fellowship Awards, PI
Publications
  • Zubcevic, Lejla, Lee, Seok-Yong. 2019. The role of Ď€-helices in TRP channel gating. Current Opinion in Structural Biology, 58, 314-323. https://doi.org/10.1016/j.sbi.2019.06.011
  • Suo, Yang, Wang, Zilong, Zubcevic, Lejla, Hsu, Allen., L., He, Qianru, Borgnia, Mario., J., Ji, Ru-Rong, Lee, Seok-Yong. 2020. Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105 (5), 882-894.e5. https://doi.org/10.1016/j.neuron.2019.11.023
  • Zubcevic, Lejla, Hsu, Allen., L, Borgnia, Mario., J, Lee, Seok-Yong. 2019. Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes. eLife, 8. https://doi.org/10.7554/elife.45779
  • Zubcevic, Lejla, Borschel, William., F, Hsu, Allen., L, Borgnia, Mario., J, Lee, Seok-Yong. 2019. Regulatory switch at the cytoplasmic interface controls TRPV channel gating. eLife, 8. https://doi.org/10.7554/elife.47746
  • Zubcevic, Lejla, Le, Son, Yang, Huanghe, Lee, Seok-Yong. 2018. Conformational plasticity in the selectivity filter of the TRPV2 ion channel. Nature Structural & Molecular Biology, 25 (5), 405-415. https://doi.org/10.1038/s41594-018-0059-z
  • Zubcevic, Lejla, Herzik, Mark., A., Wu, Mengyu, Borschel, William., F., Hirschi, Marscha, Song, Albert, Lander, Gabriel., C., Lee, Seok-Yong. 2019. Conformational Ensemble of the Human TRPV3 Ion Channel. Biophysical Journal, 116 (3), 536a. https://doi.org/10.1016/j.bpj.2018.11.2886
  • Yin, Ying, Wu, Mengyu, Zubcevic, Lejla, Borschel, William., F., Lander, Gabriel., C., Lee, Seok-Yong. 2018. Structure of the cold- and menthol-sensing ion channel TRPM8. Science, 359 (6372), 237-241. https://doi.org/10.1126/science.aan4325
  • Zubcevic, Lejla, Herzik, Mark., A, Chung, Ben., C, Liu, Zhirui, Lander, Gabriel., C, Lee, Seok-Yong. 2016. Cryo-electron microscopy structure of the TRPV2 ion channel. Nature Structural & Molecular Biology, 23 (2), 180-186. https://doi.org/10.1038/nsmb.3159