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Ken L. Seldeen, Ph.D.

Kenneth Seldeen portrait
Associate Professor, Geriatric Medicine

Research Biologist, Research Scientist, Kansas City VA Healthcare System, Research Service

kseldeen@kumc.edu

Professional Background

My goal is to investigate and implement sustainable strategies for successful aging that maintain and even enhance functional capacity, independence, and quality of life throughout aging. My expertise involves translational approaches that span the lab to the living room, including human‑relevant animal modeling of frailty, exercise, physical performance as well as muscle biology, histological analysis, metabolism and mitochondrial function. More recently my efforts include the full translation of our animal studies as the principal investigator of a 4‑year VA RRandamp;D-funded clinical trial to establish the efficacy of nicotinamide riboside (a form of vitamin B3) supplementation for functional capacity in older Veterans. At present, tens of millions of Americans are at or above 65 years of age and growing – presenting significant challenges to our healthcare systems. Therefore my research program is very well positioned to meet the growing demands for healthy living strategies that will ensure greater numbers of the population can engage in successful aging.

Education and Training
  • BS, Biology, California Lutheran University, Thousand Oaks, CA
  • PhD, Biochemistry and Molecular Biology, University of Miami, Miami, FL
  • Post Doctoral Fellowship, Biochemistry and Molecular Biology, University of Miami, Miami, FL
  • Post Doctoral Fellowship, Geriatrics, University of Miami / Miami VAHS, Miami, FL
  • Post Doctoral Fellowship, Geriatrics, University at Buffalo / VA Western New York, Buffalo, NY

Current Research and Grants
  • Impacts of nicotinamide riboside on functional capacity and muscle physiology in older Veterans, VA Rehabilitation Research and Development, PI
  • Restoring the regenerative capacity of the aged muscle”, Co investigator, NIH NIA, Co-I
Publications
  • Kwack, K., H, Zhang, L, Kramer, E., D, Thiyagarajan, R, Lamb, N., A, Arao, Y, Bard, J., E, Seldeen, K., L, Troen, B., R, Blackshear, P., J, Abrams, S., I, Kirkwood, K., L. 2022. Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells.. Frontiers in immunology, 13, 1002163
  • Choudhury, D, Rong, N, Ikhapoh, I, Rajabian, N, Tseropoulos, G, Wu, Y, Mehrotra, P, Thiyagarajan, R, Shahini, A, Seldeen, K., L, Troen, B., R, Lei, P, Andreadis, S., T. 2022. Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells.. Cell reports, 41 (9), 111744
  • Seldeen, K., L, Troen, B., R. 2021. Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?. Advances in geriatric medicine and research, 3 (2)
  • Seldeen, K., L, Shahini, A, Thiyagarajan, R, Redae, Y, Leiker, M, Rajabian, N, Dynka, A, Andreadis, S., T, Troen, B., R. 2021. Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors.. Nutrition (Burbank, Los Angeles County, Calif.), 87-88, 111189
  • Seldeen, K., L, Thiyagarajan, R, Redae, Y, Jacob, A, Troen, B., R, Quigg, R., J, Alexander, J., J. 2020. Absence of complement factor H reduces physical performance in C57BL6 mice.. Immunobiology, 225 (5), 152003
  • Seldeen, K., L, Berman, R., N, Pang, M, Lasky, G, Weiss, C, MacDonald, B., A, Thiyagarajan, R, Redae, Y, Troen, B., R. 2020. Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice.. Nutrients, 12 (10)
  • Colón-Emeric, C, Whitson, H., E, Berry, S., D, Fielding, R., A, Houston, D., K, Kiel, D., P, Rosen, C., J, Seldeen, K., L, Volpi, E, White, J., P, Troen, B., R. 2020. AGS and NIA Bench-to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders.. Journal of the American Geriatrics Society, 68 (1), 31-38
  • Seldeen, K., L, Redae, Y., Z, Thiyagarajan, R, Berman, R., N, Leiker, M., M, Troen, B., R. 2019. Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice.. Journal of visualized experiments : JoVE (144)
  • Seldeen, K., L, Redae, Y., Z, Thiyagarajan, R, Berman, R., N, Leiker, M., M, Troen, B., R. 2019. High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools.. Mechanisms of ageing and development, 180, 49-62
  • Pang, M, Rodríguez-Gonzalez, M, Hernandez, M, Recinos, C., C, Seldeen, K., L, Troen, B., R. 2019. AP-1 and Mitf interact with NFATc1 to stimulate cathepsin K promoter activity in osteoclast precursors.. Journal of cellular biochemistry, 120 (8), 12382-12392