Khursheed Iqbal, PhD
Research Assistant Professor, Pathology and Laboratory Medicine
Dr. Khursheed Iqbal, is a member of the Soares Laboratory at the Institute for Preproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, Kansas. He completed his post-doctoral training at Hannover Medical School in Germany. He has served as Research Assistant Professor since May 2016.
Education and Training
- PhD, Molecular Medicine, Hannover Medical School, Hannover, Germany
- Post Doctoral Fellowship, Placental Biology, University fo Kansas Medical Center, Kansas City, KS
- Post Doctoral Fellowship, Epigenetics, Univrsity of Nevada, Reno, NV
- Post Doctoral Fellowship, Epigenetics, University of California Davis, Davis, CA
- Post Doctoral Fellowship, Epigenetics, City Of Hope, Duarte, CA
- Society of Toxicology, Member, 2018 - Present
- Society for the Study of Reproduction, Member, 2017 - Present
Effects of endocrine disrupting chemicals (EDCs) on reproduction and pregnancy.
EDCs are environmental chemicals that interfere with critical cell signaling pathways and causes harmful developmental, reproductive, neurological, and immune effects. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that modulates gene expression facilitating adaptations to environmental changes. We investigate the impact of EDCs acting through AHR on establishment of the hemochorial placenta. Our research approach utilizes trophoblast stem cells and mutant rat models, including the development of a humanized AHR rat model possessing polymorphisms affecting AHR action, and translational experiments with human placental tissues. The actions of EDCs on placental development have profound health relevance because the placenta plays an essential role in regulating maternal health, fetal growth and maturation, and is also critical for long-term postnatal health.
Current Research and Grants
- Endocrine Disruptors, Ahr Signaling, and Placentation, NIH/NIEHS, Co-I
- Trophoblast Differentiation, NICHD/NIH, Co-I
- Iqbal, K, Tran, D., A, Li , A., X, Warden, C, Bai, A., Y, Singh, P, Wu, X, Pfeifer, G., P, Szabó, P., E. 2015. Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming.. Genome biology, 16, 59
- Iqbal, K, Chitwood, J., L, Meyers-Brown, G., A, Roser, J., F, Ross, P., J. 2014. RNA-seq transcriptome profiling of equine inner cell mass and trophectoderm.. Biology of reproduction, 90 (3), 61
- Gu, T., P, Guo, F, Yang, H, Wu, H., P, Xu, G., F, Liu, W, Xie, Z., G, Shi, L, He, X, Jin, S., G, Iqbal, K, Shi, Y., G, Deng, Z, Szabó, P., E, Pfeifer, G., P, Li , J, Xu, G., L. 2011. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.. Nature, 477 (7366), 606-10
- Iqbal, K, Jin, S., G, Pfeifer, G., P, Szabó, P., E. 2011. Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.. Proceedings of the National Academy of Sciences of the United States of America, 108 (9), 3642-7
- Iqbal, K, Kues, W., A, Baulain, U, Garrels, W, Herrmann, D, Niemann, H. 2011. Species-specific telomere length differences between blastocyst cell compartments and ectopic telomere extension in early bovine embryos by human telomerase reverse transcriptase.. Biology of reproduction, 84 (4), 723-33