Jeffrey L. Bose, PhD

Professional Background

Dr. Bose conducted undergraduate research at the University of Wisconsin-Madison studying E. coli acid tolerance and antibiotic resistance. These studies were part of his BS and MS degrees in Bacteriology and Food Science, respectively. Next he studied quorum sensing in the light-organ symbiont Vibrio fischeri during his PhD work in the Department of Microbiology at the University of Georgia. Finally, Dr. Bose switched to studying biofilm formation and virulence factor regulation of the human pathogen Staphylococcus aureus at the University of Nebraska Medical Center, first as a postdoctoral scientist and then as a non-tenure track faculty.

• BS, University of Wisconsin-Madison
• MS, University of Wisconsin-Madison
• PhD, University of Georgia
• Post Doctoral Fellowship, University of Nebraska Medical Center

Research

Overview

Dr. Bose started his laboratory at the University of Kansas Medical Center in 2014. The research of his laboratory focuses on the host-pathogen interface of infection by Staphylococcus aureus, focusing primarily on CA-MRSA strains. These studies seek to identify novel pathways that S. aureus uses to cause disease. The main projects in the lab examine how stress response pathways and fatty acid metabolism impact cell physiology, gene regulation, and pathogenesis. We accomplish this using a combination of genetics, metabolomics, transcriptomics, in vitro cell culture assays, and murine models of infection.