Halinder S. Mangat, M.D., M.Sc.
Associate Professor, Neurology
Director of Research, Director of Research, Brain Trauma Foundation, Director Of Research, Brain Trauma Foundation
Permanent Council Member, Permanent Council Member, The G4 Alliance
hmangat@kumc.eduProfessional Background
Halinder Mangat, M.D., is an associate professor in the Department of Neurology and a neurocritical care specialist with The University of Kansas Health System. He joined KU Medical Center in 2021 after eight years on the faculty at Weill Cornell Medical College in New York. He is an adjunct Assistant professor at Weill Cornell Medical College, Adjunct Associate Professor at Uniformed Services University of Health Sciences, Bethesda, and is Director of Research for the Brain trauma Foundation. Dr. Mangat also serves as a permanent council member of the G4 Alliance.
Dual certified in internal medicine and neurology, Dr. Mangat spent two years as a research fellow in neurochemistry at the Karolinska Institute in Stockholm, Sweden, and subsequently completed his fellowship in neurocritical care at Addenbrooke's Hospital/Cambridge University Hospitals, UK. He also earned a master's degree in public health for global practice from the London School of Hygiene and Tropical Medicine.
Dr. Mangat's interests are in global neurotrauma, especially in low-middle income countries. He has worked for nearly a decade in a capacity building program in Tanzania. Additionally, he dedicates research time in advanced clinical neurovascular physiology monitoring techniques using invasive devices such as cerebral microdialysis and cerebral oximetry to understand early brain injury in the acutely injured brain.
He is currently the PI on a Department of Defense funded multi center phase 1 clinical trial on safety of lumbar drainage in severe TBI, and is also funded as a subject matter and methodology liaison at the Military TBI Initiative - Brain Trauma Foundation center of excellence for Guidelines on TBI.
In addition, Dr. Mangat is part of the Global Coalition for TBI which is working towards tabling a resolution at the annual World Health Assembly meeting in 2026 to recognize TBI as a chronic and notifiable condition.
Education and Training
- MBBS, Medicine, St. John's Medical College, Bangalore, India
- MPH, Public Health for Developing Countries, London School of Hygiene & Tropical Medicine, London, United Kingdom
- Other, Respiratory Medicine, St. Johns Medical College, Bangalore, India
- Other, Neurochemistry, Karolinska Institute, Stockholm, Sweden
- Residency, Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR
- Residency, Neurology, New York University Hospital, New York, NY
- Other, Neurochemistry, Karolinska Institute, Stockholm, Sweden
- Clinical Fellowship, Neurocritical Care, University of Cambridge, Cambridge, United Kingdom
- Residency, Neurology, Mt. Sinai School of Medicine, New York, NY
Licensure, Accreditations & Certifications
- Internal Medicine Board Certification, American Board of Internal Medicine
- Kansas License, Kansas Board of Healing Arts
- Neurocritical Care, American Board of Psychiatry and Neurology
- Neurology Board Certification , American Board of Psychiatry and Neurology
Professional Affiliations
- Neurocritical Care Society, Guidelines committee, Member, 2024 - 2027
- Neurocritical Care Society, Mentor-Mentee Program, Faculty Mentor, 2020 - Present
- Neurocritical Care Society, Annual Meeting Committee, Member, 2018 - 2021
- Neurocritical Care Society, Traumatic Brain Injury Section, Co-Chair, 2017 - 2021
- Society of Critical Care Medicine, Annual Meeting Improvement Committe, Committee member, 2016 - 2020
- European Society of Intensive Care Medicine, Member, 2008 - Present
- American Academy of Neurology, Member, 2004 - Present
Current Research and Grants
- Early Lumbar drainage to Abort Severe Traumatic IntraCranial hypertension (ELASTIC): A phase 1 randomized, allocation-concealed, open-label, safety, and feasibility clinical trial, Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, PI
- The Brain Trauma Foundation – Military Traumatic Brain Injury Initiative Center for Guidelines, Military Traumatic brain Injury Initiative (MTBI2), Bethesda, Co-I
Selected Publications
- Mangat, H., S, Chiu, Y., L, Gerber, L., M, Alimi, M, Ghajar, J, Härtl, R. 2015. Hypertonic saline reduces cumulative and daily intracranial pressure burdens after severe traumatic brain injury.. Journal of neurosurgery, 122 (1), 202-10
- Mangat, H., S, Wu, X, Gerber, L., M, Schwarz, J., T, Fakhar, M, Murthy, S., B, Stieg, P., E, Ghajar, J, Härtl, R. 2020. Hypertonic Saline is Superior to Mannitol for the Combined Effect on Intracranial Pressure and Cerebral Perfusion Pressure Burdens in Patients With Severe Traumatic Brain Injury.. Neurosurgery, 86 (2), 221-230
- Mangat, H., S, Musah, A, Luedtke, S, Syed, A., A, Maramattom, B., V, Maruthanal, J, Bosman, A, Kostkova, P. 2022. Analyses of reported severe adverse events after immunization with SARS-CoV-2 vaccines in the United States: One year on.. Frontiers in public health, 10, 972464
- Hutchinson, P., J, Jalloh, I, Helmy, A, Carpenter, K., L, Rostami, E, Bellander, B., M, Boutelle, M., G, Chen, J., W, Claassen, J, Dahyot-Fizelier, C, Enblad, P, Gallagher, C., N, Helbok, R, Hillered, L, Le Roux, P., D, Magnoni, S, Mangat, H., S, Menon, D., K, Nordström, C., H, O'Phelan, K., H, Oddo, M, Perez Barcena, J, Robertson, C, Ronne-Engström, E, Sahuquillo, J, Smith, M, Stocchetti, N, Belli, A, Carpenter, T., A, Coles, J., P, Czosnyka, M, Dizdar, N, Goodman, J., C, Gupta, A., K, Nielsen, T., H, Marklund, N, Montcriol, A, O'Connell, M., T, Poca, M., A, Sarrafzadeh, A, Shannon, R., J, Skjøth-Rasmussen, J, Smielewski, P, Stover, J., F, Timofeev, I, Vespa, P, Zavala, E, Ungerstedt, U. 2015. Consensus statement from the 2014 International Microdialysis Forum.. Intensive care medicine, 41 (9), 1517-28
- Johnston, K., C, Bruno, A, Pauls, Q, Hall, C., E, Barrett, K., M, Barsan, W, Fansler, A, Van de Bruinhorst, K, Janis, S, Durkalski-Mauldin, V., L. 2019. Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial.. JAMA, 322 (4), 326-335
- Hanley, Daniel., F, Thompson, Richard., E, Rosenblum, Michael, Yenokyan, Gayane, Lane, Karen, McBee, Nichol, Mayo, Steven., W, Bistran-Hall, Amanda., J, Gandhi, Dheeraj, Mould, W., Andrew, Ullman, Natalie, Ali, Hasan, Carhuapoma, J., Ricardo, Kase, Carlos., S, Lees, Kennedy., R, Dawson, Jesse, Wilson, Alastair, Betz, Joshua., F, Sugar, Elizabeth., A, Hao, Yi, Avadhani, Radhika, Caron, Jean-Louis, Harrigan, Mark., R, Carlson, Andrew., P, Bulters, Diederik, LeDoux, David, Huang, Judy, Cobb, Cully, Gupta, Gaurav, Kitagawa, Ryan, Chicoine, Michael., R, Patel, Hiren, Dodd, Robert, Camarata, Paul., J, Wolfe, Stacey, Stadnik, Agnieszka, Money, P., Lynn, Mitchell, Patrick, Sarabia, Rosario, Harnof, Sagi, Barzo, Pal, Unterberg, Andreas, Teitelbaum, Jeanne., S, Wang, Weimin, Anderson, Craig., S, Mendelow, A., David, Gregson, Barbara, Janis, Scott, Vespa, Paul, Ziai, Wendy, Zuccarello, Mario, Awad, Issam., A, Abdul-Rahim, Azmil, Abou-Hamden, Amal, Abraham, Michael, Ahmed, Azam, Alba, Carlos., Alarcon, Aldrich, E.., Francois, Altschul, David, Amin-Hanjani, Sepideh, Anderson, Doug, Ansari, Safdar, Antezana, David, Ardelt, Agnieszka, Arikan, Fuat, Baguena, Marcelino, Baker, Alexandra, Barrer, Steven., J., Becker, Kyra., J., Bergman, Thomas, Boström, Azize, Braun, Jamie, Brindley, Peter, Broaddus, William., C., Brown, Robert, Buki, Andras, Cao, Bing, Cao, Ying, Carrion-Penagos, Julian, Chalela, Julio, Chang, Tiffany, Chorro, Indalecio., Moran, Chowdhry, Shakeel, Corral, Luisa, Csiba, Laszlo, Davies, Jason, Díaz, Alberto., Torres, Derdeyn, Colin., P., Diringer, Michael, Dlugash, Rachel, Ecker, Robert, Economas, Tracey, Enriquez, Pedro, Ezer, Erzsebet, Fan, Yuhua, Feng, Hua, Franz, Douglas, Freeman, W.., David, Fusco, Matthew, Galicich, Walter, Gelea, Mary., Leigh, Goldstein, Joshua, Gonzalez, Alejandro., Carrasco, Grabarits, Christina, Greenberg, Steven, Gress, Daryl, Gu, Eugene, Hall, Christiana, Hernandez, Fernando., Muñoz, Hoesch, Robert, Hoh, Brian., L., Houser, Jennifer, Hu, Rong, Huang, Yi, Hussain, Mohammed., Akbar, Insinga, Salvatore, Jadhav, Ashutosh, Jaffe, Jennifer, Jahromi, Babak., S., Jallo, Jack, James, Michael, James, Robert., F., Jankowitz, Brian, Jeon, Esther, Jichici, Draga, Jonczak, Karin, Jonker, Ben, Karlen, Nicki, Keric, Naureen, Kerz, Thomas, Knopman, Jared, Koenig, Carolyn, Krishnamurthy, Satish, Kumar, Avinash, Kureshi, Inam, Laidlaw, John, Lakhanpal, Arun, Latorre, Julius., Gene, Leifer, Dana, Leiphart, James, Lenington, Sarah, Li, Yunke, Lopez, George, Lovick, Darren, Lumenta, Christianto, Luo, Jinbiao, Maas, Matthew., B., MacDonald, Joel, MacKenzie, Larami, Madan, Vikram, Majkowski, Ryan, Major, Otto, Malhorta, Rishi, Malkoff, Marc, Mangat, Halinder, Maswadeh, Ahmed, Matouk, Charles, McArthur, Kate, McCaul, Scott, Medow, Joshua, Mezey, Geza, Mighty, Janet, Miller, David, Mohan, Krishna., K., Muir, Keith, Muñoz, Lorenzo, Nakaji, Peter, Nee, Alex, Nekoovaght-Tak, Saman, Nyquist, Paul, O'Kane, Roddy, Okasha, Mohamed, O'Kelly, Cian, Ostapkovich, Noeleen, Pandey, Aditya, Parry-Jones, Adrian, Perla, Krissia., Rivera, Pollack, Ania, Polster, Sean, Pouratian, Nader, Quinn, Terry, Rajajee, Ventatakrishna, Reddy, Kesava, Rehman, Mohammed, Reimer, Ronald, Rincon, Fred, Rybinnik, Igor, Sanchez, Baltasar, Sansing, Lauren, Schneck, Michael, Schuerer, Ludwig, Schul, David, Schweitzer, Jeffrey, Seder, David., B., Seyfried, Donald, Sheth, Kevin, Spiotta, Alejandro, Stechison, Michael, Szabo, Katalin, Tamayo, Gonzalo, Tanczos, Krisztian, Taussky, Philipp, Terry, John, Testai, Fernando, Thomas, Kathrine, Thompson, Carol., B., Thompson, Gregory, Torner, James., C., Tran, Huy, Tucker, Kristi, Ungar, Lior, Varelas, Panos, Vargas, Nataly., Montano, Vatter, Hartmut, Venkatasubramanian, Chitra, Vermillion, Krista, Vollmer, Dennis, Wang, Yan, Wang, Ying, Wen, Jiajun, Whitworth, Louis., Tony, Willis, Byron, Wrencher, Myriha, Wright, Shawn., E., Xu, Yongge, Yanase, Lisa, Yi, Xuxia, Yu, Zhiyuan, Zomorodi, Ali. 2019. Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial. The Lancet, 393 (10175), 1021-1032. https://doi.org/10.1016/s0140-6736(19)30195-3
- Forgacs, P., B, Allen, B., B, Wu, X, Gerber, L., M, Boddu, S, Fakhar, M, Stieg, P., E, Schiff, N., D, Mangat, H., S. 2022. Corticothalamic Connectivity in Aneurysmal Subarachnoid Hemorrhage: Relationship with Disordered Consciousness and Clinical Outcomes.. Neurocritical care, 36 (3), 760-771
- Hawryluk, Gregory., WJ, Lulla, a, Bell, Randy, Jagoda, Andy, Mangat, Halinder., S, Bobrow, B., J, Ghajar, Jamshid. 2023. Guidelines for Prehospital Management of Traumatic Brain Injury 3rd edition. Neurosurgery