Skip to main content.

Darren P. Wallace, PhD

Darren Wallace portrait
Professor, Molecular and Integrative Physiology
dwallace@kumc.edu

Professional Background

Professor
Departments of Internal Medicine


Molecular and Integrative Physiology (secondary appointment)


Director, PKD Biomarkers and Biomaterials Core


Associate Director, Kansas PKD Research and Translation Core Center


Jared Grantham Kidney Institute, Division of Nephrology and Hypertension
School of Medicine, Internal Medicine

University of Kansas Medical Center - Ph.D. (physiology)
University of Kansas Medical Center - Postdoctoral Fellowship
B.A., University of Kansas, Lawrence, KS


Research

Overview

Research Focus:
Autosomal dominant polycystic kidney disease (ADPKD) is a lethal, inherited disorder characterized by the formation and growth of numerous fluid-filled cysts, massively enlarged kidneys, and progressive loss of renal function. The disease is caused by mutations in PKD1 or PKD2, genes that encode polycystin-1 (PC-1) and polycystin-2 (PC-2), respectively. The proteins are thought to directly interact to form a Ca2+ channel that is important in intracellular Ca2+ homeostasis and signaling. Progressive expansion of cysts involves aberrant cell proliferation and the accumulation of fluid within the developing cyst cavity. As cysts grow, extracellular matrix (ECM) remodeling and the accumulation of EMC proteins lead to tissue fibrosis and a decline in kidney function.