Darren P. Wallace, PhD

Professional Background

Professor, Departments of Internal Medicine (primary appointment) and Cell Biology and Physiology (secondary appointment)
Jared Grantham Kidney Institute

Director, Kansas PKD Research and Translation Core Center (U54)
Director, PKD Biomarkers and Biomaterials Core

Education:
B.A., University of Kansas
University of Kansas Medical Center - Ph.D. (Physiology)
University of Kansas Medical Center - Postdoctoral Fellowship

Research

Overview

Research Focus:
Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder, characterized by the formation and growth of numerous fluid-filled cysts within the kidneys. Although the cysts are benign; their relentless growth leads to inflammation, fibrosis, massively enlarged kidneys, and progressive decline in renal function. My laboratory investigates cellular mechanisms responsible for aberrant cell proliferation, cyst fluid accumulation due to transepithelial Cl secretion, and pathways involved in renal inflammation, extracellular matrix remodeling and deposition, and fibrosis.