Bruce R. Troen, MD, ASGF

Professional Background

Dr. Troen is a physician-scientist formally trained in both geriatrics and molecular biology, a Fellow of the American Geriatrics Society, and has been a VA physician-investigator for more than 35 years. He is presently the Chief of the Geriatrics Division and Director of the Landon Center on Aging .

Dr. Troen joined the University of Kansas Medical Center from the University at Buffalo Jacobs School of Medicine and Biomedical Sciences where he was Professor and Chief of the Division of Geriatrics and Palliative Medicine. Additionally, Dr. Troen served as a physician-investigator with the Western New York VA Healthcare System, and Chief of Geriatric Services at Erie County Medical Center and founded the Center of Excellence for Alzheimer’s Disease of Western New York and the Center for Successful Aging at the University at Buffalo.

He Co-Chaired the NIA/AGS conference on Osteoporosis and Soft Tissue (Muscle and Fat) Disorders and was honored in 2020 to receive a University at Buffalo Exceptional Scholar – Sustained Achievement Award.

• AB, Biochemistry, Harvard College
• MD, Medicine, Harvard Medical School
• Residency, Internal Medicine, Barnes Hospital
• Post Doctoral Fellowship, Molecular Biology, Laboratory of Molecular Biology, NCI, NIH
• Clinical Fellowship, Geriatrics, University of Michigan School of Medicine

• Medicine, State of Kansas

• American Society for Bone and Mineral Research, Member, 1996 - Present
• Gerontological Society of America, Member, 1992 - Present
• American Federation for Aging Research, Member, 1991 - Present
• American Geriatrics Society, Member, 1991 - Present

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Research

Overview

Dr. Troen has several major foci of research: resilience, frailty, longevity/aging mechanisms, and osteoporosis, all of which result in great morbidity in older adults. He and his team have been elucidating what interventions can enhance physical performance, mobility, and cognition, particularly in those who are frail. Most recently, they have been investigating resilience in both pre-clinical and clinical models to understand the impacts on physical and cognitive function and the biological underpinnings, including epigenetics and metabolism. Their study on high intensity interval training was profiled in the New York Times. Dr. Troen is the Principal Investigator or Co-Investigator on biomedical translational grants from the NIH and VA, and previously from the NY State Department of Health and the State University of New York.

Research Expertise:
Biology of Aging
Frailty and Resilience
Geriatrics and Gerontology
Osteoporosis
Vitamin D

• High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans, Veteran Affairs, PI
• Impacts of nicotinamide riboside on functional capacity and muscle physiology in older veterans, VA Rehabilitation Research and Development (RR&D), Co-I
• The Biology of Frailty in People with Multiple Sclerosis, Department of Defense, Co-I

• Thiyagarajan, R, Muthaiah, R, Sreevelu, B, Treanor, O., P, Redae, Y, Berman, R, Davis, A., L, Yellapu, N, Rosario, S., R, Chaves, L., D, Seldeen, K., L, Troen, B., R. 2025. Nicotinamide riboside supplementation restores microglial health and improves cognition in aged male mice. GeroScience (2025 Nov 22. Online ahead of print)
• Thiyagarajan, R, Zhang, L, Cortez, L., A, Kwack, K., H, Maglaras, V, Yellapu, N., K, Arao, Y, Seldeen, K., L, Blackshear, P., J, Troen, B., R, Kirkwood, K., L. 2026. Increased Stability of Tristetraprolin mRNA Supports Bone Health and Decreases Frailty During Aging. Aging and Disease
• Seldeen, K., L, Saha, S, Tang, Z, Van Sciver, A, Treadway, C., L, Treanor, O., P, Satchidanand, N, Troen, B., R. 2025. Provocative testing in community dwelling older adults: a path to identify physical resilience.. The journals of gerontology. Series A, Biological sciences and medical sciences, 80 (12)
• Seldeen, K., L, Wang, N, Muthaiah, R, Treanor, O., P, Davis, A., L, Chaves, L., D, Thiyagarajan, R, Marzullo, B., J, Yergeau, D., A, Troen, B., R. 2025. High-Intensity Interval Exercise Drives Vitamin D Receptor Expression in Skeletal Muscle via Recruitment of Non-Parenchymal Cells, Not Upregulation in Muscle Fibers.. Nutrients, 17 (23)
• Seldeen, K., L, Rahman, A., S, Redae, Y, Satchidanand, N, Mador, M., J, Ma, C, Soparkar, M, Lima, A., R, Ezeilo, I., N, Troen, B., R. 2024. VO2MAX, 6-minute walk, and muscle strength each correlate with frailty in US veterans.. Frontiers in physiology, 15, 1393221
• Al Worikat, N, Molaei, F, Zanotto, A, Tabatabaei, A, Lynch, S., G, Troen, B., R, Sosnoff, J., J, Zanotto, T. 2024. Frailty in multiple sclerosis: A scoping review.. Multiple sclerosis and related disorders, 92, 106157
• Seldeen, K., L, McDonald, B., A, Troen, B., R, Duque, G, Troen, B., R. 2022. Frailty: The end of the osteosarcopenia continuum? In “Osteosarcopenia” (Duque G and Troen BR, Eds.) – Elsevier, London, UK, pp. 239-253
• Duque, G, Fatima, M, Zanker, J, Troen, B., R. 2022. Osteoporosis. In "Hazzard's Principles of Geriatric Medicine and Gerontology" – 8th edition, McGraw-Hill, New York, NY, pp. 759-778
• Montero-Odasso, M, van der Velde, N, Martin, F., C, Petrovic, M, Tan, M., P, Ryg, J, Aguilar-Navarro, S, Alexander, N., B, Becker, C, Blain, H, Bourke, R, Cameron, I., D, Camicioli, R, Clemson, L, Close, J, Delbaere, K, Duan, L, Duque, G, Dyer, S., M, Freiberger, E, Ganz, D., A, Gómez, F, Hausdorff, J., M, Hogan, D., B, Hunter, S., MW, Jauregui, J., R, Kamkar, N, Kenny, R., A, Lamb, S., E, Latham, N., K, Lipsitz, L., A, Liu-Ambrose, T, Logan, P, Lord, S., R, Mallet, L, Marsh, D, Milisen, K, Moctezuma-Gallegos, R, Morris, M., E, Nieuwboer, A, Perracini, M., R, Pieruccini-Faria, F, Pighills, A, Said, C, Sejdic, E, Sherrington, C, Skelton, D., A, Dsouza, S, Speechley, M, Stark, S, Todd, C, Troen, B., R, van der Cammen, T, Verghese, J, Vlaeyen, E, Watt, J., A, Masud, T. 2022. World guidelines for falls prevention and management for older adults: a global initiative.. Age and ageing, 51 (9)
• Troen, B., R. 2021. Falls: To D or Not to D-That Is Not the (Only) Question!. Annals of internal medicine, 174 (2), 261-262