Bruce R. Troen, M.D., ASGF

Professional Background

Dr. Troen is a physician-scientist formally trained in geriatrics and molecular biology, a Fellow of the American Geriatrics Society, and has been a VA physician-investigator for more than 35 years. He was recently Co-Chair of the NIA/AGS conference on Osteoporosis and Soft Tissue (Muscle and Fat) Disorders and was honored in 2020 to receive a University at Buffalo Exceptional Scholar – Sustained Achievement Award.

Dr. Troen joined the University of Kansas Medical Center from the University at Buffalo Jacobs School of Medicine and Biomedical Sciences where he was Professor and Chief of the Division of Geriatrics and Palliative Medicine. Additionally, Dr. Troen served as a physician-investigator with the Western New York VA Healthcare System, and Chief of Geriatric Services at Erie County Medical Center and founded the Center of Excellence for Alzheimer’s Disease of Western New York and the Center for Successful Aging at the University at Buffalo.

• AB, Biochemistry, Harvard College
• MD, Medicine, Harvard Medical School
• Residency, Internal Medicine, Barnes Hospital
• Post Doctoral Fellowship, Molecular Biology, Laboratory of Molecular Biology, NCI, NIH
• Clinical Fellowship, Geriatrics, University of Michigan School of Medicine

• American Society for Bone and Mineral Research, Member, 1996 - Present
• Gerontological Society of America, Member, 1992 - Present
• American Federation for Aging Research, Member, 1991 - Present
• American Geriatrics Society, Member, 1991 - Present

Research

Overview

Dr. Troen has several major foci of research: frailty, longevity/aging mechanisms, and osteoporosis, all of which result in great morbidity in older adults. He and his team have been elucidating what interventions can enhance physical performance, mobility, and cognition, particularly in those who are frail. Their study on high intensity interval training was profiled in the New York Times. Dr. Troen is the Principal Investigator or Co-Investigator on biomedical translational grants from the NIH and VA, and previously from the NY State Department of Health and the State University of New York.

Research Expertise:
Biology of Aging
Frailty
Geriatrics and Gerontology
Osteoporosis
Vitamin D

• Enhancing Geroscience Faculty Development and Scholarship in Order to Minimize Frailty and Maximize Healthspan, NIH National Institute of Aging, PI
• Post-Transcriptional Control of Aging-Associated Inflammation and Bone Homeostasis, NIH NIDCR, Co-I
• High intensity interval training and nicotinamide riboside treatment to enhance functional capacity and reduce frailty during aging, Veterans Affairs, PI

• Montero-Odasso, M, van der Velde, N, Martin, F., C, Petrovic, M, Tan, M., P, Ryg, J, Aguilar-Navarro, S, Alexander, N., B, Becker, C, Blain, H, Bourke, R, Cameron, I., D, Camicioli, R, Clemson, L, Close, J, Delbaere, K, Duan, L, Duque, G, Dyer, S., M, Freiberger, E, Ganz, D., A, Gómez, F, Hausdorff, J., M, Hogan, D., B, Hunter SMW, Jauregui, J., R, Kamkar, N, Kenny, R., A, Lamb, S., E, Latham, N., K, Lipsitz, L., A, Liu-Ambrose, T, Logan, P, Lord, S., R, Mallet, L, Marsh, D, Milisen, K, Moctezuma-Gallegos, R, Morris, M., E, Nieuwboer, A, Perracini, M., R, Pieruccini-Faria, F, Pighills, A, Said, C, Sejdic, E, Sherrington, C, Skelton, D., A, Dsouza, S, Speechley, M, Stark, S, Todd, C, Troen, B., R, van der Cammen, T, Verghese, J, Vlaeyen, E, Watt, J., A, Masud, T. 2022. World guidelines for falls prevention and management for older adults: a global initiative.. Age and ageing, 51 (9)
• Kwack, K., H, Zhang, L, Kramer, E., D, Thiyagarajan, R, Lamb, N., A, Arao, Y, Bard, J., E, Seldeen, K., L, Troen, B., R, Blackshear, P., J, Abrams, S., I, Kirkwood, K., L. 2022. Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells.. Frontiers in immunology, 13, 1002163
• Elkin, P., L, Resendez, S, Mullin, S, Troen, B., R, Mammen, M., J, Chang, S, Franklin, G, McCray, W, Brown, S., H. 2022. Leukotriene inhibitors with dexamethasone show promise in the prevention of death in COVID-19 patients with low oxygen saturations.. Journal of clinical and translational science, 6 (1), e74
• Troen, B., R. 2021. Falls: To D or Not to D-That Is Not the (Only) Question!. Annals of internal medicine, 174 (2), 261-262
• Shahini, A, Rajabian, N, Choudhury, D, Shahini, S, Vydiam, K, Nguyen, T, Kulczyk, J, Santarelli, T, Ikhapoh, I, Zhang, Y, Wang, J, Liu, S, Stablewski, A, Thiyagarajan, R, Seldeen, K, Troen, B., R, Peirick, J, Lei, P, Andreadis, S., T. 2021. Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo.. Science advances, 7 (36), eabe5671
• Seldeen, K., L, Troen, B., R. 2021. Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?. Advances in geriatric medicine and research, 3 (2)
• Seldeen, K., L, Shahini, A, Thiyagarajan, R, Redae, Y, Leiker, M, Rajabian, N, Dynka, A, Andreadis, S., T, Troen, B., R. 2021. Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors.. Nutrition (Burbank, Los Angeles County, Calif.), 87-88, 111189
• Seldeen, K., L, Thiyagarajan, R, Redae, Y, Jacob, A, Troen, B., R, Quigg, R., J, Alexander, J., J. 2020. Absence of complement factor H reduces physical performance in C57BL6 mice.. Immunobiology, 225 (5), 152003
• Seldeen, K., L, Berman, R., N, Pang, M, Lasky, G, Weiss, C, MacDonald, B., A, Thiyagarajan, R, Redae, Y, Troen, B., R. 2020. Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice.. Nutrients, 12 (10)
• Colón-Emeric, C, Whitson, H., E, Berry, S., D, Fielding, R., A, Houston, D., K, Kiel, D., P, Rosen, C., J, Seldeen, K., L, Volpi, E, White, J., P, Troen, B., R. 2020. AGS and NIA Bench-to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders.. Journal of the American Geriatrics Society, 68 (1), 31-38