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Alan S. Yu, M.B., B.Chir.

Alan Yu portrait
Harry Statland and Solon Summerfield Professor of Medicine, Nephrology and Hypertension

Director, Manage daily activities of the division., The Jared Grantham Kidney Institute, SOM-Kansas City

Director, Oversee daily activities in Division., SOM-Kansas City, Division of Nephrology and Hypertension

ayu@kumc.edu

Professional Background

Alan S. L. Yu, M.B., B.Chir. is the Harry Statland and Solon Summerfield Endowed Professor of Medicine, Director of the Jared Grantham Kidney Institute, and Director of the Division of Nephrology and Hypertension at the University of Kansas Medical Center.

Dr. Yu received his medical degree from the University of Cambridge, England and completed his internship and residency in internal medicine, and clinical and research fellowships in nephrology at the Brigham and Women's Hospital, Harvard Medical School. He is an elected member of the American Society of Clinical Investigation and a Fellow of the American College of Physicians.

Dr. Yu's primary research interests are in kidney physiology, epithelial cell biology, and polycystic kidney disease (PKD). He is the principal investigator for CRISP, the longest running cohort study of PKD, Director of the Clinical Research Core for the NIH-funded Kansas PKD Research and Translation Core Center, and a principal investigator for the Kansas Institute for Precision Medicine COBRE. Dr. Yu has published over 100 scientific papers, chapters and reviews, and is the lead editor for the 11th edition of "Brenner andamp; Rector's The Kidney", the best-selling nephrology textbook worldwide.

Education and Training
  • BA, Univ. of Cambridge
  • MBChB, Univ. of Cambridge
  • Residency, Internal Medicine, Brigham and Women's Hospital, Boston, MA
  • Post Doctoral Fellowship, Nephrology, Brigham and Women's Hospital, Boston, MA
  • Clinical Fellowship, Nephrology, Brigham and Women's Hospital, Boston, MA
Licensure, Accreditations & Certifications
  • Internal Medicine, American Board of Internal Medicine
  • Nephrology, American Board of Internal Medicine
Professional Affiliations
  • American College of Physicians, Fellow, 2015 - Present
  • American Society for Clinical Investigation, Member, 2010 - Present

Research

Overview

Dr. Yu's primary research interests are in kidney physiology, epithelial cell biology, and polycystic kidney disease (PKD). The focus of his laboratory is on the role of tight junctions in the regulation of paracellular epithelial permeability. He conducts clinical and translational research to develop new prognostic biomarkers and therapies for PKD. Dr. Yu is the principal investigator for CRISP, the longest running cohort study of PKD, Director of the Clinical Research Core for the NIH-funded Kansas PKD Research and Translation Core Center, and a principal investigator for the Kansas Institute for Precision Medicine COBRE.

Current Research and Grants
  • Role of claudin-2 in calcium homeostasis and kidney stone disease, NIH, PI
  • Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) IV: Prognosis for End Stage Renal Disease and Biomarker Validation, NIH, PI
  • The Kansas Institute for Precision Medicine, NIH
  • Kansas PKD Research and Translation Core Center, NIH
Publications
  • Curry, J., N, Saurette, M, Askari, M, Pei, L, Filla, M., B, Beggs, M., R, Rowe, P., S, Fields, T, Sommer, A., J, Tanikawa, C, Kamatani, Y, Evan, A., P, Totonchi, M, Alexander, R., T, Matsuda, K, Yu, A., S. 2020. Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease.. The Journal of clinical investigation, 130 (4), 1948-1960
  • Pei, L, Solis, G, Nguyen, M., T, Kamat, N, Magenheimer, L, Zhuo, M, Li , J, Curry, J, McDonough, A., A, Fields, Timothy., A, Welch, W., J, Yu, Alan., Shiu Leun. 2016. Paracellular epithelial sodium transport maximizes energy efficiency in the kidney.. The Journal of clinical investigation, 126 (7), 2509-18
  • Yu ASL, Shen, C, Landsittel, D., P, Grantham, J., J, Cook, L., T, Torres, V., E, Chapman, A., B, Bae, K., T, Mrug, M, Harris, P., C, Rahbari-Oskoui, F., F, Shi, T, Bennett, W., M. 2019. Long-term trajectory of kidney function in autosomal-dominant polycystic kidney disease.. Kidney international, 95 (5), 1253-1261
  • Yu ASL, Shen, C, Landsittel, D., P, Harris, Penelope , Torres, V., E, Mrug, M, Bae, K., T, Grantham, J., J, Rahbari-Oskoui, F., F, Flessner, M., F, Bennett, W., M, Chapman, A., B. 2018. Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease.. Kidney international, 93 (3), 691-699