Neurotrophic Factors
Schematic representation of a dorsal root ganglion (DRG) neuron expressing receptors for the neurotrophin nerve growth factor (NGF). Certain DRG neurons bind NGF that is synthesized in the skin, internalize the receptor-ligand complex, and retrogradely transport both to the cell body where it exerts biological actions on the neuron. The lab is interested in how various neural injury or disease affect this process.