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Sensory Nerve Disorder Lab
School of Medicine  :  Department of Anatomy and Cell Biology  :  Sensory Nerve Disorder Lab  :   Lab Members

Karra Muller

Position

MD/PhD Student

Education

B.S. in Chemistry 2003
Emory University
Atlanta, GA

Previous Positions

Research Assistant: Emory University School of Medicine
Department of Neurology
Lab of Michael Decker, PhD
2003-2004

Undergraduate Student Researcher: Centers for Disease Control and Prevention
NCID, DVRD, Influenza Branch
2001-2003

Current Research

I am currently investigating the effects of diabetic polyneuropathy on large sensory nerve fibers and concomitant deficits in sensorimotor function, balance, and gait. Using a mouse model of Type I diabetes I am quantifying subtle sensorimotor deficits and further characterizing aberrant large fiber innervation in muscle spindles and cutaneous mechanoreceptors. In addition, I am working on improving the sensorimotor deficits through aerobic exercise therapy and insulin treatment.

Publications

  1. Muller KA, Ryals JM, Feldman EL, Wright DE. Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice. Diabetes 2008 Mar 24 (Epub ahead of print).
  2. Levant B, Ozias MK, Jones KA, Carlson SE. Differential effects of modulation of docosahexaenoic acid content during development in specific regions of rat brain. Lipids 2006 May;41(5):407-414.
  3. Decker MJ, Jones KA, Solomon IG, Keating GL, Rye DB. Reduced extracellular dopamine and increased responsiveness to novelty: neurochemical and behavioral sequelae of intermittent hypoxia. Sleep 2005;28(2):169-176

Published Abstracts

  1. Jones KA, Ryals JM, Fowler SC, Wright DE (2007) Exercise treatment for altered sensorimotor function in diabetic mice. Soc. Neurosci. Abst.
  2. Jones KA, Ryals JM, Pinkston J, Fowler SC, Wright DE. (2007) Assessment of large fiber proprioceptive deficits and sensory fiber innervation in diabetic mice. J. Peripher. Nerv. Syst.
  3. Jones KA, Ryals JM, Johnson MS, Wright DE. (2006) Assessment of large fiber proprioceptive deficits and spindle innervation in diabetic mice. Soc. Neurosci. Abst. 43.14.
  4. Jones KA, Carter S, Shoemaker JT, Solomon IG, Lah J, Levey A, Decker MJ. (2004) Intermittent hypoxic insults occurring during a period of critical brain development reduce the expression of insoluble beta amyloid within the hippocampus. Alzheimer’s and Dementia.
  5. Jones KA, Solomon IG, Keating GL, Rye DB, Decker MJ. (2004) Reduced extracellular dopamine in the striatum of juvenile rats exposed to intermittent hypoxia as neonates. Sleep.
  6. Jones KA, Solomon IG, Keating GL, Rye DB, Decker MJ. (2004) Amphetamine mediated release of dopamine is markedly enhanced in juveniles exposed to intermittent hypoxia as neonates. Sleep.

Presentations: Oral

  1. “Proprioceptive deficits and large sensory fiber innervation in diabetic mice.” University of Kansas Medical Center Student Research Forum, Kansas City, KS. 2007.
  2. “Assessment of proprioceptive deficits and spindle innervation in diabetic mice.” University of Kansas Medical Center Student Research Forum, Kansas City, KS. 2006.
  3. “Reduced extracellular dopamine in the striatum of juvenile rats exposed to intermittent hypoxia as neonates.” Associated Professional Sleep Societies, Philadelphia, PA. June 2004.

Presentations: Poster

  1. "Exercise treatment for altered sensorimotor function in diabetic mice." Neuroscience, San Diego, CA. Nov. 2007.
  2. “Assessment of large fiber proprioceptive deficits and sensory fiber innervation in diabetic mice.” Meeting of the Peripheral Nerve Society, Snowbird, Utah July 2007.
  3. “Assessment of large fiber proprioceptive deficits and spindle innervation in diabetic mice.” Neuroscience, Atlanta, GA. Nov. 2006.
  4. “Amphetamine mediated release of dopamine is markedly enhanced in juveniles exposed to intermittent hypoxia as neonates.” Associated Professional Sleep Societies, Philadelphia, PA. June 2004.

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