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Nutrition and Prostate Cancer

Nutrition and Prostate Cancer
Obesity increases the risk of prostate cancer mortality. Prostate cancer is the most common cancer diagnosed in men and the second-most common cause of cancer-related mortality in men. Obesity prevalence does not differ between men and women; however, strategies for weight control have focused almost entirely on women.

A photo of the lab bench showing samples and testing equipment

Above: Analyzing samples for the EDGE lab's PCa GRIT clinical trial
for prostate cancer patients. Scientists are measuring adipokine
levels in serum samples.

Data suggest that men respond better to a program targeted towards their needs and bent (i.e., related to masculinity), emphasizing competition, autonomy, technology, cost savings, and male-specific values or barriers to change. 

The relationship between obesity and fatal prostate cancer is established, but it is unknown if losing weight reduces the risk of prostate cancer and associated mechanisms responsible for the reduced risk. Furthermore, we expect that non-cancer health benefits from the diet intervention will substantially improve overall patient outcomes (QOL, CVD risk, glycemic control). This was a pilot study with a goal to better understand the influence of energy balance on prostate cancer progression.

Based on findings from our pilot study, PCa GRIT, the Weight-management Aimed to Reduce Risk and Improve Outcomes from Radical Prostatectomy (WARRIOR) study tests the impact of weight management on obesity-driven immune and inflammatory biomarkers for prostate cancer recurrence, death, and quality of life. The goal of this study is to help men live longer after prostate surgery while improving their quality of life and helping to prevent cancer from ever returning.

Enrollment for this study is open. Questions? Contact Misty Bechtel

Principal Investigator


Jill Hamilton-Reeves photo

The EDGE lab is led by Jill Hamilton-Reeves, PhD, RD, CSO, a registered and licensed dietitian with doctoral training in translational and clinical nutrition science. See her bio

Last modified: Sep 28, 2018

Want to participate in a clinical trial?
Please contact Misty Bechtel 913-945-5037

Updates & Activities

Hamilton-Reeves was awarded a $2.8 million R37 grant from the National Institutes of Health and National Cancer Institute for her project entitled Effect of Immune-Enhancing Nutrition on Radical Cystectomy Outcomes. Her project aims to assess the effectiveness of specialized immunonutrition intake before and after bladder cancer surgery compared to a control to reduce post-operative complications.

Hamilton-Reeves was invited to be a keynote speaker at the ERAS 2018 World Congress event in Stockholm, Sweden. She presented the State of the Art Lecture: Perioperative nutritional support to cystectomy patients. Hamilton-Reeves' publication, Perioperative Immunonutrition Modulates Inflammatory Response after Radical Cystectomy: Results of a Pilot Randomized Controlled Clinical Trial was selected for continuing medical education (CME) credit in the August 2018 issue of The Journal of Urology. Hers is one of only five articles selected from each issue to contribute a question to be answered for CME credit.

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