Mary Lynn Bajt-Jaeschke, PhD

Research Associate Professor
B.S., Auburn University, 1980
M.S., Michigan State University, 1982
Ph.D., Michigan State University, 1989


Research Interests

Acetaminophen hepatotoxicity is currently the most frequent cause of acute liver failure in the US and many European countries. However, exact mechanisms of acetaminophen-induced cell injury and regeneration are incompletely understood. My current research focuses on the intracellular signaling mechanisms of acetaminophen-induced cell necrosis, in particular the role of mitochondrial endonucleases in nuclear DNA fragmentation. In addition, I am studying the role of neutrophils in regeneration after acetaminophen overdose.

 

Selected Publications

Bajt, M.L., Knight, T.R., Farhood, A., and Jaeschke, H.: Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice. Journal of Pharmacology and Experimental Therapeutics 307: 67-73, 2003.

 Bajt, M.L., Knight, T.R., Lemasters, J.J., and Jaeschke, H.: Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicological Sciences 80: 343-349, 2004.

Dorman, R., Gujral, J.S., Bajt, M.L., Farhood, A., and Jaeschke, H.: Generation and functional significance of CXC chemokine formation for neutrophil-induced liver injury during endotoxemia. American Journal of Physiology Gastrointestinal Liver Physiology 288: G880-G886, 2005.

Cover, C., Mansouri, A., Knight, T.R., Bajt, M.L., Lemasters, J.J., Pessayre, D., and Jaeschke, H.: Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. Journal of Pharmacology and Experimental Therapeutics 315: 879-887, 2005.

Jaeschke, H., and Bajt, M.L.: Intracellular signaling mechanisms of acetaminophen-induced liver cell death (Invited Review), Toxicological Sciences89: 31-41, 2006.

Jaeschke, H., Cover, C., and Bajt, M.L.: Role of caspases in acetaminophen-induced liver injury. Life Sciences 78: 1670-1676, 2006.

Cover, C., Liu, J., Farhood, A., Malle, E., Waalkes, M.P., Bajt, M.L., and Jaeschke, H.: Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicology and Applied Pharmacology 216: 98-107, 2006.

 Bajt, M.L., Cover, C., Lemasters, J.J., and Jaeschke, H.: Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen hepatotoxicity. Toxicological Sciences 94: 217-225, 2006.

 Bajt, M.L., Farhood, A., Lemasters, J.J., and Jaeschke, H.: Mitochondrial Bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity. Journal of Pharmacology and Experimental Therapeutics 324: 8-14, 2008.

Andringa, K.K., Bajt, M.L., Jaeschke, H., and Bailey, S.M.: Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase.Toxicology Letters 177: 188-197, 2008.

 Bajt, M.L., Yan, H.-M., Farhood, A., and Jaeschke, H.: Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose. Toxicological Sciences 104: 419-427, 2008.

Williams, C.D., Bajt, M.L., Farhood, A., and Jaeschke, H.: Acetaminophen-induced hepatic neutrophil recruitment and liver injury in CD18-deficient mice.Liver International 30: 1280-1292, 2010.

Yan, H.M., Ramachandran, A., Bajt, M.L., Lemasters, J.J., and Jaeschke, H.: The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in primary cultured hepatocytes. Toxicological Sciences 117: 515-523, 2010.

 Bajt, M.L., Ramachandran, A., Lebofsky, M., Yan, H.M., Farhood, A., Lemasters, J.J., and Jaeschke, H.: Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity. Toxicological Sciences 122: 598-605, 2011.

Jaeschke, H., Williams, C.D., Ramachandran, A., and Bajt, M.L.: Acetaminophen hepatotoxicity and repair: role of sterile inflammation and innate immunity (Invited Review). Liver International 32: 8-20, 2012.

Woolbright, B.L., Ramachandran, A., McGill, M.R., Yan, H.M., Bajt, M.L., Sharpe, M.R., Lemasters, J.J., and Jaeschke, H.: Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity. Basic & Clinical Pharmacology and Toxicology 111: 417-425, 2012.

Last modified: Feb 12, 2013

Bajt-Jaeschke

Contact

Mary Lynn Bajt-Jaeschke, PhD
Research Associate Professor

4018 HLSIC; MS-1018
3901 Rainbow Blvd.
Kansas City, Kansas 66160

P: (913) 588-9184
F: (913) 588-7501
mbajt@kumc.edu

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