Feng Li, PhD

Research Assistant Professor
Ph.D., in Organic Chemistry, University of Stuttgart, Germany, 2007

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I obtained my Ph.D. in Organic Chemistry in 2007 from University of Stuttgart in Germany. From 2007 to 2009, I worked at National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH) as a visiting fellow. In 2009, I joined the laboratory of Dr. Ma as a postdoctoral fellow.

Research Interests

Drug metabolism, Drug-induced liver injury, Toxicometabolomics

My research focuses on mechanisms of hepatotoxicity caused by anti-HIV and anti-tuberculosis (TB) drugs. The role of CYP3A-mediated metabolic activation in anti-HIV/TB drug-induced liver injury is investigated in genetically engineered PXR and CYP3A mouse models. An LC-MS-based metabolomic approach is used to profile: (1) reactive metabolites of anti-HIV/TB drugs and (2) biomarkers of anti-HIV/TB drug-induced liver injury. 

Selected Publications

Feng Li, Jie Lu, Xiaochao Ma, Metabolomic screening and identification of bioactivation pathways of ritonavir, Chem. Res. Toxicol. 2011, Oct 31. [Epub ahead of print]

Feng Li, Jie Lu, Xiaochao Ma, CPY3A4-mediated lopinavir bioactivation and its inhibition by ritonavir, Drug. Metab. Dispos. 2011 Sep 27. [Epub ahead of print]

Feng Li, Yan Miao, Lirong Zhang, Sarah Ann Neuenswander, Douglas Justin, and Xiaochao Ma Metabolomic analysis reveals novel isoniazid metabolites and hydrazones in human urine, Drug Metab. Pharmacokinet. 2011 August 16. [Epub ahead of print]

Ying Guo, Feng Li, Xiaochao Ma; Xingguo Cheng; Honghao Zhou; Curtis D Klaassen, CYP2D plays a major role in berberine metabolism in liver of mice and humans, Xenobiotica 2011, 41, 996-1005.

Feng Li, John E. Folk, Kejun Cheng, Muneaki Kurimura, Jason A. Deck, Jeffrey R. Deschamps, Richard B. Rothman, Christina M. Dersch, Arthur E. Jacobson, Kenner C. Rice, Probes for narcotic receptor mediated phenomena. 43. Synthesis of the ortho-a and para-a, and improved synthesis and optical resolution of the ortho-b and para-b oxide-bridged phenylmorphans: Compounds with moderate to low opioid-receptor affinity, Bioorg. Med. Chem. 2011, 19, 4330-4337.

Feng Li, Jie Lu, Xiaochao Ma, Profiling the Reactive Metabolites of Xenobiotics Using Metabolomic Technologies, Chem. Res. Toxicol. 2011, 24, 744-751.

Feng Li, Jie Lu, Laiyou Wang, and Xiaochao Ma, CYP3A-Mediated Generation of Aldehyde and Hydrazine in Atazanavir Metabolism, Drug. Metab. Dispos. 2011, 39, 394-401.

Laiyou Wang, Feng Li, Jie Lu, Guodong Li, Dan Li, Xiao-bo Zhong, Grace L. Guo, Xiaochao Ma, The Chinese Herbal Medicine Sophora Flavescens Activates Pregnane X Receptor, Drug. Metab. Dispos. 2010, 38, 2226-2231.

Sida Niu, Feng Li, Dun-Xian Tan, Lirong Zhang, Jeffrey R. Idle, Frank J. Gonzalez, Xiaochao Ma, Analysis of N1-acetyl-N2-formyl-5-methoxykynuramine/N1-acetyl-5-methoxy-kynuramine formation from melatonin in mice, J Pineal Res. 2010, 49, 106-114. (co-first author)

Feng Li, Laiyou Wang, Grace Guo, Xiaochao Ma, Metabolism mediated drug interactions associated with ritonavir-boosted tipranavir in mice, Drug. Metab. Dispos. 2010, 38, 871-878.

Feng Li, Zhao-Ming Li, Hua Yang, Volker Jäger, New approaches to branched beta-amino alpha-hydroxy acids, taxol side-chain analogs, Z. Naturforsch. 2008, 63b, 431-446.

Feng Li, Oliver Schwardt, Volker Jäger, Synthesis of (2S,3R,4S)-isonorstatine using a solvent-induced highly stereoselective 3-butenyl addition to L-threose imines, Synthesis 2006, 2173-2182.