B.A. in Biology, University of Missouri-Kansas City
Ph.D. in Toxicology, University of Kansas Medical Center
Born and raised in beautiful Kansas City, I earned a B.A. in biology at the University of Missouri - Kansas City in 2007 and a Ph.D. in Toxicology at the University of Kansas Medical Center in 2013. While an undergraduate, I worked for two years as a lab technician. Through that experience, I developed an interest in research and was inspired to pursue graduate school. For my dissertation work, I joined the lab of Dr. Hartmut Jaeschke and investigated issues of clinical relevance with regard to the mechanisms of APAP hepatotoxicity. In particular, I became strongly interested in the development and improvement of blood biomarkers for APAP hepatotoxicity. As a post-doc, I am continuing this work and expanding to study other drugs and environmental toxins.
Acetaminophen (APAP) is one of the most used drugs in the world, but overdose of APAP is the chief cause of acute liver failure in many Western countries. Working in the Jaeschke lab, I am involved in studies designed to lead us to a better understanding of the physiological mechanisms of APAP hepatotoxicity. Although much progress has been made in this field using rodent models, the relevance of these data to humans is still not certain. To rectify this, we are taking a translational approach, incorporating human samples and improved in vitro human hepatocyte models into our other work. We are also investigating the mechanisms of microcystin hepatotoxicity. In addition to standard laboratory techniques (histology, enzyme kinetics, PCR, western blotting), my work has grown (and continues to grow) to include a number of fascinating analytical and molecular tools.
Williams CD, McGill MR, Farhood A, Jaeschke H. (2013) Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress. Food Chem Tox. Submitted.
McGill MR, Williams CD, Jaeschke H. (2013) Liver Toxicology. In Mammalian Toxicology. Hoboken: Wiley. Submitted. (Book chapter)
McGill MR, Lebofsky M, Norris HR, Slawson, MH, Bajt ML, Xie Y, Williams CD, Wilkins DG, Rollins DE, Jaeschke H. (2013) Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. Toxicol Appl Pharmacol. In press.
McGill MR, Jaeschke H. (2013) Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. In press. (Review)
McGill MR and Jaeschke H. (2013) Antioxidants in liver disease. In Drug-induced Liver Injury, 3rd Edition. Elsevier. In press. (Book chapter)
McGill MR, Ramachandran A, Jaeschke H. (2013) Oxidative stress and drug-induced liver injury. In Systems Biology of Free Radicals and Antioxidants. Heidelberg: Springer. In press. (Book chapter)
Jaeschke H, Williams CD, McGill MR, Xie Y, Ramachandran A. (2013) Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products. Food Chem Toxicol. 55, 279-89. (Review)
Jaeschke H, McGill MR, Williams CD. (2013) The pathophysiological relevance of neutrophils in acetaminophen hepatotoxicity. Hepatology. 57, 419. (Letter)
Xie Y, Williams CD, McGill MR, Lebofsky M, Ramachandran A, Jaeschke H. (2013) Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting P450 isoenzymes not inflammasome activation. Toxicol Sci. 131, 325-35.
Woolbright BL, Ramachandran A, McGill MR, Yan HM, Bajt ML, Sharpe MR, Lemasters JJ, Jaeschke H. (2012) Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity. Basic Clin Pharmacol Toxicol. 111, 417-25.
Jaeschke H, Williams CD, McGill MR. (2012) Caveats of using acetaminophen hepatotoxicity models for natural product testing. Toxicol Lett. 215, 40-1. (Letter)
McGill MR*, Williams CD*, Xie Y, Ramachandran A, Jaeschke H. (2012) Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanisms of toxicity. Toxicol Appl Pharmacol. 264, 387-94.
Aubert J, Begriche K, Delannoy M, Morel I, Pajaud J, Ribault C, Lepage S, McGill MR, Lucas-Clerc C, Turlin B, Robin MA, Jaeschke H, Fromenty B. (2012) Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. J Pharmacol Exp Ther. 342, 676-87.
Ni HM, Boggess N, McGill MR, Lebofsky M, Borude P, Apte U, Jaeschke H, Ding WX. (2012) Liver specific loss of Atg5 protects against acetaminophen-induced liver injury. Toxicol Sci. 127, 438-50.
Antoine DJ, Jenkins RE, Dear JW, Williams DP, McGill MR, Sharpe MR, Craig DG, Simpson KJ, Jaeschke H, Park BK. (2012) Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J Hepatol. 56, 1070-9.
McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H. (2012) Mechanisms of acetaminophen hepatotoxicity in humans and mice involve mitochondrial damage and nuclear DNA fragmentation. J Clin Invest. 122, 1574-83.
Jaeschke H, McGill MR, Ramachandran A. (2011). Oxidant stress, mitochondria and intracellular death mechanisms in drug-induced liver injury. Drug Metab Rev. 44, 88-106. (Review)
Jaeschke H, McGill MR, Ramachandran A. (2011). Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 121, 428-30. (Letter)
Jaeschke H, McGill MR, Williams CD, Ramachandran A. (2011). Current Issues with acetaminophen hepatotoxicity - a clinically relevant model to test the efficacy of natural products. Life Sci. 16, 2448-50. (Review)
McGill MR*, Yan HM*, Ramachandran A, Murray GJ, Rollins DE, Jaeschke H. (2011). HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity. Hepatology. 53, 974-82.
Jaeschke H, Williams CD, McGill MR, Farhood A. (2010). Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity. World J Gastroenterol. 16, 2448-50. (Letter)
Katayama H, McGill M, Kearns A, Brzozowski M, Degner N, Harnett B, Kornilayev B, Matkovic-Calogovic D, Holyoak T, Calvet JP, Gogol EP, Seed J, Fisher MT. (2009) Strategies for folding of affinity tagged proteins using GroEL and osmolytes. J Struct Funct Genomics. 10, 57-66.*Co-first authors
Mitch McGill, PhD
4018 HLSIC; MS 1018
3901 Rainbow Blvd.
Kansas City, Kansas 66160
F: (913) 588-7501