Kevin Beggs, PhD

Postdoctoral Fellow - Apte Lab
B.S. in Chemistry, Alma College
Ph.D. in Toxicology, Michigan State University


Biography

Before moving to Kansas I spent my entire life in Michigan.  I received my BS in chemistry from Alma College in 2006.  After that, I pursued a graduate education in toxicology at Michigan State University in the Department of Pharmacology and Toxicology and the Center for Integrative Toxicology.  Working with Dr. Robert Roth and Dr. Patricia Ganey, my thesis work at MSU consisted of investigating mechanisms underlying idiosyncratic drug-induced liver injury.  I received my doctorate in Pharmacology and Toxicology in 2013.  In collaboration with Dr. Udayan Apte, I wrote a research proposal seeking funding from the Department of Pharmacology, Toxicology and Therapeutics training grant at the University of Kansas Medical Center.  In 2014 the proposal was accepted and I am currently working with Dr. Apte as a postdoctoral fellow.

Research Interests

The transcription factor human nuclear factor 4-alpha (HNF4a) is a master regulator of hepatocellular differentiation, and also regulates liver growth.  My research investigates the role and function of HNF4a in the liver in response to environmental carcinogens.  A greater understanding of the mechanisms involved in the development and progression of hepatocellular carcinoma can offer novel therapeutic interventions for the treatment of liver cancer.

Publications

Poulsen KL, Olivero-Verbel J, Beggs KM, Ganey PE, Roth RA. (2014) Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-α by Macrophages: Role of the DNA Damage Response. J Pharmacol Exp Ther. Jul;350(1):164-70.

Beggs KM, Fullerton AM, Miyakawa K, Ganey PE, Roth RA. (2014) Molecular mechanisms of hepatocellular apoptosis induced by trovafloxacin-tumor necrosis factor-alpha interaction. Toxicol Sci. Jan;137(1):91-101.

Zou W, Beggs KM, Sparkenbaugh EM, Jones AD, Younis HS, Roth RA, Ganey PE. (2009) Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury.
J Pharmacol Exp Ther.
Oct;331(1):114-21.

Shaw PJ, Beggs KM, Sparkenbaugh EM, Dugan CM, Ganey PE, Roth RA. (2009) Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. Toxicol Sci. Oct;111(2):288-301.

Linder AE, Beggs KM, Burnett RJ, Watts SW. (2009) Body distribution of infused serotonin in rats. Clin Exp Pharmacol Physiol. May;36(5-6):599-601.

Last modified: Jul 30, 2014

kbeggs2

Contact

Kevin Beggs, PhD
Postdoctoral Fellow - Apte Lab

4052 HLSIC; MS 1018
3901 Rainbow Blvd.
Kansas City, Kansas 66160

P: (913) 945-6821
F: (913) 588-7501
kbeggs2@kumc.edu

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