Yuan Li

Graduate Student - Ding Lab
B.Med.in Clinical Medicine, Huazhong University of Science & Technology, Wuhan, China
B.A. in English Language and Literature, Central China Normal University, Wuhan, China

I grew up and went to college in Wuhan, China. I majored in clinic medicine in Huazhong University of Science & Technology, and minored in English Language and Literature in the collaborating Central China Normal University. After graduation in 2011, I studied in the Liver Research Institute in the affiliated Tongji Hospital, and in 2012 came to U.S. and attended the IGPBS program of KUMC. Intrigued by liver functioning and diseases I joined Dr. Wen-Xing Ding's lab in 2013, pursuing a Ph.D. degree. Outside the lab I enjoy reading books and exploring new things in the city.

Research interests
Macroautophagy is a cellular degradation pathway involved in the trafficking of long-lived proteins and cellular organelles to the lysosome for degradation to maintain cellular homeostasis. Reduced autophagy has been implicated in neurodegenerative diseases, metabolomics syndrome and cancer, along with accumulation of protein aggregates and damaged mitochondria. In contrast, increased autophagy has been shown to protect against tissue injury. Our lab has employed a high-throughput image-based screening for autophagy modulators. Screening compounds have been applied alone or with chloroquine (CQ) to cells, and GFP-labeled LC3 puncta are quantified to measure the autophagy flux. Several novel autophagy inducers and inhibitors have been identified. And under Dr. Ding's guidance, I am interested in further analyzing several potential modulators and characterizing their effect on autophagy as well as the molecular mechanism. Our long term goal is to utilize these novel autophagy modulators to treat acetaminophen/ethanol-induced liver injury and fatty-liver as well as liver fibrosis.

Last modified: Jan 08, 2018

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Yuan Li
Graduate Student - Ding Lab

4036 HLSIC; MS 1018
3901 Rainbow Blvd.
Kansas City, Kansas 66160

P: (913) 588-4744