Sharon Manley

Graduate Student - Ding Lab
BS in Biology, Concordia University, Wisconsin


Originally from a dairy farm in north central Wisconsin, I graduated summa cum laude with a BS in Biology from Concordia University Wisconsin in 2007. Shortly after, I did research for a couple of years at Medical College of Wisconsin in their gastroenterology department studying the effects and mechanisms of the drugs to inflammation response in inflammatory bowel disease, particularly the Crohn's Disease. I ended up here at KUMC because of their atmosphere, and well, solid reputed programs. When I'm not in the lab, I enjoy running with my two dogs, bicycling and doing outdoor activities with my husband.

Research Interests

Under guidance of my mentor, Dr Wen Xing Ding, my research focuses on the mechanisms of autophagy in liver injury and tumorigenesis, especially when mediated by bile acid and farnesoid X receptor (FXR), a nuclear receptor. FXRis found mainly in the liver and intestines. FXR is reported to regulate the bile acids level in liver and when activated, it inhibits the bile acid synthesis. Furthermore, FXR knockout mice subsequently have higher hepatic bile acids level and develop spontaneous liver tumors. However how the deficiency of FXR leads to liver cancer is not known. Autophagy is a cell survival mechanism and has been proposed to act as a tumor suppressor although the mechanism for the latter is less clear. I am investigating the role of FXR in potentially suppressing autophagy regulation via modulating transcription of p62, an ubiquitin binding protein and an autophagy substrate. I am also investigating the non-transcription-mediated suppression of autophagy by bile acids.

My research could impact the understanding of the intracellular mechanisms leading up to bile acids and FXR-deficiency mediated hepatocellular carcinoma but also the general mechanisms for the suppression of tumorigenesis by autophagy.

Last modified: Dec 04, 2012

smanley

Contact

Sharon Manley
Graduate Student - Ding Lab

4034 HLSIC; MS 1018
3901 Rainbow Blvd.
Kansas City, Kansas 66160

P: (913) 588-9180
F: (913) 588-7501
smanley@kumc.edu

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