Mitch McGill

Graduate Student - Jaeschke Lab
B.A. in Biology, University of Missouri-Kansas City

Born and raised in Kansas City, MO, I earned a BA in biology at the University of Missouri - Kansas City in 2007.  While an undergraduate, I worked for two years as a research technician under George J. Thomas, Jr., PhD, and James M. Benevides, PhD, in the Department of Cell Biology & Biophysics.  Through this experience, I developed an interest in research and was inspired to pursue graduate school.  I chose KUMC because of the diversity of research programs and the friendly people.

Research Interests

Acetaminophen (APAP) is an extremely common over the counter medication. Overdose of APAP is the principal cause of acute liver failure in the Western world. Working in the Jaeschke lab, I am involved in studies designed to lead us to a better understanding of the physiological mechanism of APAP toxicity. Although much progress has been made in this field using rodent models, the relevance of these data to humans is uncertain. To rectify this, we are taking a translational approach, incorporating human samples and improved in vitrohuman hepatocyte models into our other work.

Publications

McGill MR, Yan HM, Ramachandran R, Murray GJ, Rollins DE, Jaeschke H. HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity. 2010. Submitted.

Jaeschke H, Williams CD, McGill MR, Farhood A. Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity. World J Gastroenterol. 2010 May 21;16(19):2448-50. 

Katayama H, McGill M, Kearns A, Brzozowski M, Degner N, Harnett B, Kornilayev B, Matkovic-Calogovic D, Holyoak T, Calvet JP, Gogol EP, Seed J, Fisher MT. Strategies for folding of affinity tagged proteins using GroEL and osmolytes. J Struct Funct Genomics. 2009 Mar;10(1):57-66. PMID: 19082872