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Melissa Ruggiero

Graduate Student - Hagenbuch Lab


I was born in Cincinnati, Ohio but moved to the Kansas City, Missouri area at the age of five, where I currently still reside. I earned my bachelor's degree in Chemistry with an emphasis in Medicinal Chemistry from Northwest Missouri State University in Maryville, Missouri in the Spring of 2015. While in my junior year at NWMSU, I was introduced to the prospect of graduate school, KUMC, and the Pharmacology, Toxicology and Therapeutics department through the ASPET SURF program. After graduating from NWMSU I joined the IGPBS program in the Fall 2015. I subsequently joined Dr. Hagenbuch's lab in the Summer of 2016.

 

Research Interest
I am currently interested and am taking part in three different projects within the lab. First of which I am interested in the functional consequences of the co-expression of hepatic transporters such as OATP1B3 and OCT1. Next, using the Phage Display technique, I am attempting to develop antibodies specific for the closely related transporters OATP1B1, OATP1B3 and the mouse homolog OATP1B2. Finally, I am working on the identification of rheostat positions within NTCP. These are amino acid positions at which point mutations or polymorphisms alter the function of NTCP gradually, depending on the amino acid residue that replaces the original residue, without turning the function completely off.

 

Last modified: Sep 28, 2018

Melissa Ruggiero

Contact

Melissa Ruggiero
Graduate Student - Hagenbuch Lab

4038A HLSIC; MS 1018
3901 Rainbow Blvd.
Kansas City, Kansas 66160

P: (913) 588-9189
mruggiero@kumc.edu

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