Kuo Du

Graduate Student - Jaeschke Lab
B.S in Pharmacy, China Pharmaceutical University


I come from Guangxi Province of China. After 4 years undergraduate study in China Pharmaceutical University, I got my B.S degree in Pharmacy and then came to KUMC for my graduate study in 2011. With a high interest in Pharmacology and Toxicology, I joined Dr. Jaeschke's lab to pursue my Ph.D. degree in Toxicology after one year study and research rotation in IGPBS.

Research Interests

Acetaminophen (APAP) is a widely used over-the-counter analgesic and antipyretic drug in the western countries. While it is safe at therapeutic doses, it would cause severe hepatotoxicity when taken at overdoses, which is the leading cause of acute liver failure in both the United States and the United Kingdom.

The hepatotoxicity of APAP is initiated by the formation of a reactive metabolite, NAPQI, which could deplete glutathione and bind to cellular proteins, especially the proteins in mitochondria. The mitochondria protein binding will result in mitochondrial oxidant stress and dysfunction, which then lead to nuclear DNA damage and finally cell necrosis. Although many progresses have been made after decades of research, the intracellular signaling mechanisms of its hepatotoxicity are needed to be further revealed. A better understanding of the signaling mechanism should provide us the therapeutic strategies in the clinic.

Last modified: Dec 04, 2012

kdu

Contact

Kuo Du
Graduate Student - Jaeschke Lab

4020 HLSIC; MS 1018
3901 Rainbow Blvd.
Kansas City, Kansas 66160

P: (913) 588-9183
F: (913) 588-7501
kdu@kumc.edu

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