Kishore Polireddy

Graduate Student - Chen Lab
B.Sc. Biotechnology, GOVT Arts College for Men, Anantapur, India
M.Sc. Biochemistry, University of Hyderabad, Hyderabad, India


I am originally from Andhra Pradesh, India. I received my undergraduate degree in Biotechnology from Govt.Arts College, Anantapur and master's degree in Biochemistry from University of Hyderabad. I joined IGPBS in 2009. After completing IGPBS, I joined Dr. Qi Chen's lab to pursue my PhD degree in Toxicology.

Research Interests

Since its discovery Ascorbate (Vitamin C) is well known as an anti-oxidant molecule. The basic function of ascorbate is the prevention of scurvy. Currently ascorbic acid is the most widely used vitamin supplement throughout the world. Ascorbic acid is widely distributed in fresh fruits and vegetables. Physiological functions of ascorbic acid are largely dependent on the redox properties of this vitamin. Ascorbic acid is a cofactor for hydroxylases and monooxygenase enzymes involved in the synthesis of collagen, carnitine and neurotransmitters. The contention that ascorbate is involved in resistance to neoplasia gains support from several studies demonstrating that cancer patients have abnormally low ascorbate reserves. Nobel laureate Linus Pauling advocated use of high dose ascorbate (>10g/day) to treat cancer. High dose ascrobate improved the quality of life, prolongation of survival time in terminal patients and complete regression in some cases. Since then, ascrobate gain importance as an anti-cancer agent. Importantly, from oral ingestion ascorbate plasma concentrations are tightly controlled at less than 100 µM. Only parenteral administration (e.g. IV or IP) can achieve concentrations sufficiently high (mM) to affect cancer cells. Our lab has been working on mechanistic point of view how ascorbate selectively targets cancer cells or how it sensitizes cancer cells to commonly used chemotherapeutic drugs. Recent evidences also showed that epithelial mesenchymal transition (EMT) play an important role in tumor progression and metastasis. I am currently studying the role of ascorbate in EMT modulation and tumor metastasis. . I am also setting efforts to establish a High through-put screening approach for discovery of other innovative EMT inhibitors.


Selected publication

Kishore Polireddy, Hemantkumar Chavan, BasharA. Abdulkarim, Partha Krishnamurthy., Functional significance of the ATP-binding cassette transporter B6 in hepatocellular carcinoma (2011) Molecular Oncology 5: 410-425.

Abstract

Kishore Polireddy and Nancy A. Rice., Searching for binding partners for the phosphorylase kinase variant PhK 181 (2009) FASEB J. (Meeting Abstract) LB292.


Last modified: Dec 05, 2013

kpolireddy

Contact

Kishore Polireddy
Graduate Student - Chen Lab

G001 Wahl Hall East, MS1018
3901 Rainbow Blvd.
Kansas City, Kansas 66160

P: (913) 945-6873
F: (913) 588-7501
kpolireddy@kumc.edu

ID=x9987