Kelli Boxberger

Graduate Student - Lampe Lab
B.S. in Chemistry, Fort Hays State University, Hays, KS


Born and raised in Topeka, KS, I earned a Bachelor of Science in Chemistry from Fort Hays State University, Hays, KS, in 2010. I became interested in pursuing a career in research during a summer Undergraduate Research Program (URP) in the Department of Pharmaceutical Chemistry at the University of Kansas in 2009. I joined the IGPBS program at KUMC in the fall of 2010, and am currently pursuing a degree in Pharmacology in the lab of Dr. Jed Lampe.

Research Interests

My research in the Lampe Lab is centered around two distinct foci: one involving the organic cation transporter, OCT1, and the other, the antiapoptotic protein, Survivin.

OCT1 is a member of the SLC22 family of transporters and is responsible for the transport of a wide variety of positively charged small molecules, including ion channel blockers, psychoactive drugs, antivirals, antidiabetics, antineoplastic agents and endogenous monoamine neurotransmitters. The goal of this project is to elucidate the structure of OCT1 and correlate these findings with those of in vivo functional assays. This will involve several techniques, including molecular dynamics simulations, 2D-NMR analysis and uptake studies in mammalian cell lines.

Alongside my OCT1 studies, I will be aiding in the pursuit of discovering small molecule inhibitors of Survivin. Survivin is a member of the Inhibitor of Apoptosis (IAP) family of proteins and is involved in both mitosis and apoptosis. Its function in inhibiting apoptosis is of particular interest to our lab because of its high levels of expression in many cancers. The goal of this project is to identify small molecule inhibitors of Survivin, as a means of cancer therapy, using several different fluorescence techniques, as well as 2D-NMR analysis.

Last modified: Jan 05, 2013

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Contact

Kelli Boxberger
Graduate Student - Lampe Lab

4012 HLSIC, MS 1018
3901 Rainbow Blvd.
Kansas City, Kansas 66160

P: (913) 588-9181
F: (913) 588-7501
kboxberger@kumc.edu

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