James Weemhoff

Graduate Student - Jaeschke Lab


I was born in Florida and grew up in New Hampshire where I attended college at the University of New Hampshire and earned my B.S. in Animal Science.  Following college, I worked as a research technician at Tufts University in the Department of Pharmacology and Experimental Therapeutics, where I studied cytochrome P450s and active drug transport systems in relationship to drug pharmacokinetics, drug-drug interactions, and safety/tolerability.  Following this, I attended veterinary school at Kansas State University and subsequently worked as an emergency veterinarian prior to coming to KUMC for my PhD.  I chose KUMC for my graduate studies because of the great reputation they have as a research institution.

 

Research Interests

I am beginning my work in Dr. Jaeschke's lab where I will be studying the mechanisms of ischemia/reperfusion injury on the liver.  During periods of ischemia, such as with liver transplantation, hepatocytes release damage-associated molecular patterns, or DAMPS, which induce an inflammatory response leading to liver injury, and potential transplant rejection.  The cellular mechanisms of this oxidative stress and subsequent injury will be the focus of my project. 

 

Publications

Von Moltke LL, Weemhoff JL, Khan IA, Harmatz JS, Goldman P, and Greenblatt DJ. Inhibition of Human Cytochromes P450 By Components of Ginkgo Biloba. J Pharm Pharmacol. 2004 Aug;56(8):1039-44.

Weemhoff JL, Von Moltke LL, Richert C, Hesse LM, Harmatz JS, and Greenblatt DJ. Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir. J Pharm Pharmacol. 2003 Mar;55(3):381-6.

Von Moltke LL, Weemhoff JL, Perloff MD, Hesse LM, Harmatz JS, Roth-Schechter BF, and Greenblatt DJ. Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein. Biopharm Drug Dispos. 2002 Dec;23(9):361-7.

Last modified: May 30, 2013

James Weemhoff, DVM

Contact

James Weemhoff
Graduate Student - Jaeschke Lab

4020 HLSIC; MS 1018
3901 Rainbow Blvd.
Kansas City, Kansas 66160

P: (913) 588-9183
F: (913) 588-7501
jweemhoff@kumc.edu

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