Briana Holt

Graduate Student - Pritchard Lab

Born and raised in the Kansas City Metropolitan area, I graduated magna cum laude with my Bachelor of Science in Biological Sciences and a minor in Mathematics from the University of Missouri-Kansas City in 2011.  My interest in the field of research stemmed from undergraduate research under Leonard Dobens, PhD, studying the genetics of border cell migration in the Drosophila ovary.  After taking a gap year to volunteer for special needs children in South America, I'm pursuing a PhD in the department of Pharmacology/Toxicology here at KUMC under Dr. Michele Pritchard to one day take my science training internationally.


Research Interests:

In Dr. Pritchard's lab we are interested in liver fibrosis, which is regarded as the final stage of liver disease in which the liver can regenerate itself. In patients with cirrhosis, a more advanced form of liver disease, liver transplantation is required. Therefore, understanding the mechanisms that promote fibrosis will help us to develop novel therapeutics to halt and reverse liver disease progression. The hepatic stellate cell - the main cell type responsible for the excessive deposition of extracellular matrix - gives the liver its fibrogenic phenotype.

My research interests are in Egr-1, an immediate-early response transcription factor implicated in protection from hepatic fibrosis.  I am working with Egr-1 -/-  mice to understand how the loss of Egr-1 affects HSC activation (using primary HSCs) and liver fibrogenesis (using a method of ethanol-accelerated carbon tetrachloride-induced fibrosis).

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Briana Holt


Briana Holt
Graduate Student - Pritchard Lab

4006 HLSIC; MS 1018
3901 Rainbow Blvd.
Kansas City, Kansas 66160

P: (913) 945-6651
F: (913) 588-7501