Bharat Bhushan

Graduate Student - Apte Lab
B. Pharmacy, University of Delhi, India
M.S. Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research, Mohali, India

Born and brought up in New Delhi (India), I got a Bachelor in Pharmacy from the University of Delhi. After completing M.S. (Pharmacology & Toxicology) from the National Institute of Pharmaceutical Education & Research (Mohali, India), I worked as a Senior Research Associate for two years with the Toxicology Group of Evalueserve, a Delhi based Knowledge Process Outsourcing firm. Then I joined IGPBS program of KUMC and currently I am pursuing Ph.D. degree (Toxicology) in Dr. Udayan Apte's lab.

Research Interests

Overdose of acetaminophen (APAP) is the major cause of acute liver failure (ALF) in the Western World, accounting for close to 50% of the ALF cases in the US. Currently, treatment options for APAP-overdose patients are extremely limited. Liver has an extraordinary capacity to regenerate in response to liver injury. Recent studies suggest that compensatory liver regeneration is a critical determinant of overall survival following APAP-overdose. However, the mechanisms of liver regeneration following APAP-induced ALF are not known. We are interested in studying these mechanisms with overall hypothesis that stimulating liver regeneration can be a potential therapeutic option for APAP-overdose. We are particularly interested in investigating role of Wnt/β-catenin pathway in liver regeneration following APAP-induced ALF and targeting this pathway therapeutically for APAP-overdose.