Ph.D., University of Innsbruck, 1973
Toxicology, halogenated hydrocarbons, dioxin
My research is aimed at elucidating the mechanism of toxicity of chlorinated aromatic hydrocarbons (CAH) and related compounds. The cause of 2,3,7,8-tetrachlorodibenzo-r-dioxin-induced death in rats is a combination of appetite suppression and inhibition of gluconeogenesis, whereas in mice it appears to be inhibition of gluconeogenesis alone, leading to a lethal hypoglycemia. Currently three lines of research are being pursued: 1) elucidation of the molecular mechanism(s) of action leading to CAH-induced enzyme inhibition; 2) investigation of the subchronic and chronic toxicities of TCDD and its higher chlorinated homologues as well as other heterocyclic analogues such as chlorinated phenothiazines (CPT), and 3) studying female reproductive toxicity of both CAH and CPT.
Ushinohama, K., Son, D.-S., Roby, K.F., Rozman, K.K. and Terranova, P.F.: Impaired ovulation by 2,3,7,8-tetrachlorodibenzo-r-dioxin (TCDD) in immature rats treated with equine chorionic gonadotropin. Reprod. Toxicol. 15:275-280, 2001.
Petroff, B.K,. Gao, X., Ohshima, K.-I., Shi, F.X., Son, D.-S., Roby, K.F., Rozman, K.K., Taya, K. and Terranova, P.F.: Effect of 2,3,7,8-tetrachlorodibenzo-r-dioxin (TCDD) on serum inhibin concentrations and inhibin immunostaining during follicular development in female Sprague-Dawley rats. Reprod. Toxicol. 16:97-105, 2002.
Son, D.S., Roby, K.F., Roxman, K.K. and Terranova, P.F.: Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-r-dioxin in a mouse ovarian cancer cell line. Toxicology 176:229-243, 2002.
Rozman, K.K. and Doull, J.: Derivation of an occupational exposure limit (OEL) for n-Propyl Bromide. App. Occ. Env. Hyg. 17:711-716, 2002.
Son, D.S. and Rozman, K.K.: 2,3,7,8-Tetrachlorodibenzo-r-dioxin (TCDD) induces plasminogen activator inhibitor-1 through an aryl hydrocarbon receptor-mediated pathway in mouse hepatoma cell lines. Arch. Toxicol. 76:404-413, 2002.
Gao, X., Petroff, B.K., Oluola, O., Georg, G., Rozman, K.K. and Terranova, P.F.: Endocrine disruption by inodo-c-carbinol and tamoxifen-blockage of ovulation. Toxicol. Appl. Pharmacol. 183:170-188, 2002.